000095786 001__ 95786
000095786 005__ 20210902121700.0
000095786 0247_ $$2doi$$a10.3389/fnbeh.2019.00296
000095786 0248_ $$2sideral$$a117315
000095786 037__ $$aART-2020-117315
000095786 041__ $$aeng
000095786 100__ $$aArenas, M. Carmen
000095786 245__ $$aPrepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine
000095786 260__ $$c2020
000095786 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095786 5203_ $$aPrepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this disorder are also involved in the regulation of PPI. Recently, we have reported that baseline PPI levels in mice can predict their sensitivity to the conditioned reinforcing effects of cocaine in the conditioned place preference (CPP) paradigm. Mice with a low PPI presented a lower sensitivity to the conditioned rewarding effects of cocaine; however, once they acquired conditioned preference with a higher dose of the drug, a more persistent associative effect of cocaine with respect to environmental cues was evident in these animals when compared with High-PPI mice. Therefore, we proposed that the PPI paradigm can determine subjects with a higher vulnerability to the effects of cocaine. Developing locomotor sensitization after pre-exposure to cocaine is considered an indicator of transitioning from recreational use to a compulsive consumption of the drug. Thus, the aim of the present study was to evaluate whether subjects with a low PPI display a higher locomotor sensitization induced by cocaine. First, male and female OF1 mice were classified as High- or Low-PPI according to their baseline PPI levels. Subsequently, the motor effects induced by an acute dose of cocaine (Experiments 1 and 2) and the development of locomotor sensitization induced by pre-exposure to this drug (Experiments 3 and 4) were recorded using two apparatuses (Ethovision and actimeter). Low-PPI mice presented low sensitivity to the motor effects of an acute dose of cocaine, but a high increase of activity after repeated administration of the drug, thus suggesting a great developed behavioral sensitization. Differences after pretreatment with cocaine vs. saline were more pronounced among Low-PPI subjects than among High-PPI animals. These results endorse our hypothesis that the PPI paradigm can detect subjects who are more likely to display behaviors induced by cocaine and which can increase the risk of developing a cocaine use disorder. Herein, we further discuss whether a PPI deficit can be considered an endophenotype for cocaine use disorder.
000095786 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0007$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2015-69649-R
000095786 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095786 590__ $$a3.558$$b2020
000095786 591__ $$aBEHAVIORAL SCIENCES$$b13 / 53 = 0.245$$c2020$$dQ1$$eT1
000095786 591__ $$aNEUROSCIENCES$$b144 / 273 = 0.527$$c2020$$dQ3$$eT2
000095786 592__ $$a1.26$$b2020
000095786 593__ $$aBehavioral Neuroscience$$c2020$$dQ1
000095786 593__ $$aNeuropsychology and Physiological Psychology$$c2020$$dQ1
000095786 593__ $$aCognitive Neuroscience$$c2020$$dQ1
000095786 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095786 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, María Carmen$$uUniversidad de Zaragoza
000095786 700__ $$aMiñarro, José
000095786 700__ $$aManzanedo, Carmen
000095786 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000095786 773__ $$g13 (2020), 296 [11 pp.]$$pFrontiers in behavioral neuroscience$$tFRONTIERS IN BEHAVIORAL NEUROSCIENCE$$x1662-5153
000095786 8564_ $$s1132448$$uhttps://zaguan.unizar.es/record/95786/files/texto_completo.pdf$$yVersión publicada
000095786 8564_ $$s481932$$uhttps://zaguan.unizar.es/record/95786/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095786 909CO $$ooai:zaguan.unizar.es:95786$$particulos$$pdriver
000095786 951__ $$a2021-09-02-09:13:47
000095786 980__ $$aARTICLE