95786 20210902121700.0 doi 10.3389/fnbeh.2019.00296 sideral 117315 ART-2020-117315 eng Arenas, M. Carmen Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine 2020 Access copy available to the general public Unrestricted Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this disorder are also involved in the regulation of PPI. Recently, we have reported that baseline PPI levels in mice can predict their sensitivity to the conditioned reinforcing effects of cocaine in the conditioned place preference (CPP) paradigm. Mice with a low PPI presented a lower sensitivity to the conditioned rewarding effects of cocaine; however, once they acquired conditioned preference with a higher dose of the drug, a more persistent associative effect of cocaine with respect to environmental cues was evident in these animals when compared with High-PPI mice. Therefore, we proposed that the PPI paradigm can determine subjects with a higher vulnerability to the effects of cocaine. Developing locomotor sensitization after pre-exposure to cocaine is considered an indicator of transitioning from recreational use to a compulsive consumption of the drug. Thus, the aim of the present study was to evaluate whether subjects with a low PPI display a higher locomotor sensitization induced by cocaine. First, male and female OF1 mice were classified as High- or Low-PPI according to their baseline PPI levels. Subsequently, the motor effects induced by an acute dose of cocaine (Experiments 1 and 2) and the development of locomotor sensitization induced by pre-exposure to this drug (Experiments 3 and 4) were recorded using two apparatuses (Ethovision and actimeter). Low-PPI mice presented low sensitivity to the motor effects of an acute dose of cocaine, but a high increase of activity after repeated administration of the drug, thus suggesting a great developed behavioral sensitization. Differences after pretreatment with cocaine vs. saline were more pronounced among Low-PPI subjects than among High-PPI animals. These results endorse our hypothesis that the PPI paradigm can detect subjects who are more likely to display behaviors induced by cocaine and which can increase the risk of developing a cocaine use disorder. Herein, we further discuss whether a PPI deficit can be considered an endophenotype for cocaine use disorder. info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0007 info:eu-repo/grantAgreement/ES/MINECO/PSI2015-69649-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.558 2020 BEHAVIORAL SCIENCES 13 / 53 = 0.245 2020 Q1 T1 NEUROSCIENCES 144 / 273 = 0.527 2020 Q3 T2 1.26 2020 Behavioral Neuroscience 2020 Q1 Neuropsychology and Physiological Psychology 2020 Q1 Cognitive Neuroscience 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Blanco-Gandía, María Carmen Universidad de Zaragoza (orcid)0000-0001-5990-1266 Miñarro, José Manzanedo, Carmen 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 13 (2020), 296 [11 pp.] Frontiers in behavioral neuroscience FRONTIERS IN BEHAVIORAL NEUROSCIENCE 1662-5153 1132448 http://zaguan.unizar.es/record/95786/files/texto_completo.pdf Versión publicada 481932 http://zaguan.unizar.es/record/95786/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95786 articulos driver 2021-09-02-09:13:47 ARTICLE