95789 20230519145346.0 doi 10.1016/j.transproceed.2020.08.029 sideral 120252 ART-2021-120252 eng Benito, R. Universidad de Zaragoza (orcid)0000-0001-5134-1006 Clinical Outcome in Human T-Lymphotropic Virus Type 2 Carriers Following Organ Transplantation 2021 Access copy available to the general public Unrestricted Background: Frequent and rapid development of myelopathy has been reported in individuals with human T-lymphotropic virus type 1 (HTLV-1) infection following solid organ transplantation. There is no information regarding HTLV-2, a closely related virus that often infects injection drug users. Methods: This study includes a retrospective analysis of all consecutive organ transplants performed during the last 2 decades at a large reference transplantation unit in Spain. All participants were tested for anti-HTLV antibodies. Results: A total of 2019 individuals were tested for HTLV during the study period, including 663 potential donors and 1356 recipient candidates. Twelve (0.59%) were reactive on initial HTLV serologic screening, but only 6 (all recipients) were confirmed as positive, all for HTLV-2. Two recipients underwent liver transplantation and have remained asymptomatic despite being on tacrolimus for 4 and 8 years, respectively. Likewise, the remaining 4 HTLV-2 carriers have not developed clinical complications potentially associated with HTLV-2. Conclusions: Unlike HTLV-1 infection, HTLV-2 infection in the transplantation setting does not seem to be associated with rapid development of neurologic complications, Given the cross-seroreactivity between HTLV-1 and HTLV-2, discriminatory rapid tests are urgently needed and would reduce unnecessary organ discharge. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 1.014 2021 IMMUNOLOGY 159 / 163 = 0.975 2021 Q4 T3 TRANSPLANTATION 24 / 26 = 0.923 2021 Q4 T3 SURGERY 191 / 214 = 0.893 2021 Q4 T3 0.286 2021 Transplantation 2021 Q3 Surgery 2021 Q3 1.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gil, J. (orcid)0000-0002-2037-3213 Sahagún, J. Universidad de Zaragoza Soriano, V. 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 53, 2 (2021), 743-745 Transplant. proc. Transplantation Proceedings 0041-1345 200283 http://zaguan.unizar.es/record/95789/files/texto_completo.pdf Versión publicada 30773 http://zaguan.unizar.es/record/95789/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95789 articulos driver 2023-05-18-13:20:56 ARTICLE