95801 20230921135435.0 doi 10.3390/vaccines8030459 sideral 120239 ART-2020-120239 eng Roy, S. Impact of pre-existing immunity on live attenuated influenza vaccine-induced cross-protective immunity 2020 Access copy available to the general public Unrestricted The efficacy of the intranasally (i.n.) delivered live attenuated influenza vaccine (LAIV) is variable and, in some seasons, suboptimal. In this study, we report that LAIV exhibits cross-protective efficacy in mice, potentially associated with cellular immunity as opposed to antigen-specific antibody responses. However, pre-exposure to the intramuscularly (i.m.) delivered inactivated influenza vaccine (IIV) severely impaired LAIV-induced cross-protection against heterologous challenge, potentially by inhibiting replication of LAIV. Our findings suggest that pre-existing immunity afforded by IIV suppresses cross-protective T cell immunogenicity of LAIV. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.422 2020 MEDICINE, RESEARCH & EXPERIMENTAL 63 / 140 = 0.45 2020 Q2 T2 IMMUNOLOGY 74 / 162 = 0.457 2020 Q2 T2 1.296 2020 Drug Discovery 2020 Q1 Immunology 2020 Q1 Pharmacology (medical) 2020 Q1 Pharmacology 2020 Q1 Infectious Diseases 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Williams, C.M. Pardo, J. Universidad de Zaragoza (orcid)0000-0003-0154-0730 Wijesundara, D.K. Furuya, Y. 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 8, 3 (2020), 459 [1-6 pp.] Vaccines 2076-393X 466242 http://zaguan.unizar.es/record/95801/files/texto_completo.pdf Versión publicada 503025 http://zaguan.unizar.es/record/95801/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95801 articulos driver 2023-09-21-13:30:58 ARTICLE