000095862 001__ 95862
000095862 005__ 20210902121615.0
000095862 0247_ $$2doi$$a10.3389/fphys.2019.01582
000095862 0248_ $$2sideral$$a116386
000095862 037__ $$aART-2020-116386
000095862 041__ $$aeng
000095862 100__ $$aVan Duijvenboden, S
000095862 245__ $$aComplex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System
000095862 260__ $$c2020
000095862 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095862 5203_ $$aBackground: Recent clinical, experimental and modeling studies link oscillations of ventricular repolarization in the low frequency (LF) (approx. 0.1 Hz) to arrhythmogenesis. Sympathetic provocation has been shown to enhance both LF oscillations of action potential duration (APD) and beat-to-beat variability (BVR) in humans. We hypothesized that beta-adrenergic blockade would reduce LF oscillations of APD and BVR of APD in humans and that the two processes might be linked.
Methods and Results: Twelve patients with normal ventricles were studied during routine electrophysiological procedures. Activation-recovery intervals (ARI) as a conventional surrogate for APD were recorded from 10 left and 10 right ventricular endocardial sites before and after acute beta-adrenergic adrenergic blockade. Cycle length was maintained constant with right ventricular pacing. Oscillatory behavior of ARI was quantified by spectral analysis and BVR as the short-term variability. Beta-adrenergic blockade reduced LF ARI oscillations (8.6 ± 4.5 ms2 vs. 5.5 ± 3.5 ms2, p = 0.027). A significant correlation was present between the initial control values and reduction seen following beta-adrenergic blockade in LF ARI (rs = 0.62, p = 0.037) such that when initial values are high the effect is greater. A similar relationship was also seen in the beat-to beat variability of ARI (rs = 0.74, p = 0.008). There was a significant correlation between the beta-adrenergic blockade induced reduction in LF power of ARI and the witnessed reduction of beat-to-beat variability of ARI (rs = 0.74, p = 0.01). These clinical results accord with recent computational modeling studies which provide mechanistic insight into the interactions of LF oscillations and beat-to-beat variability of APD at the cellular level.
Conclusion: Beta-adrenergic blockade reduces LF oscillatory behavior of APD (ARI) in humans in vivo. Our results support the importance of LF oscillations in modulating the response of BVR to beta-adrenergic blockers, suggesting that LF oscillations may play role in modulating beta-adrenergic mechanisms underlying BVR.
000095862 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095862 590__ $$a4.566$$b2020
000095862 591__ $$aPHYSIOLOGY$$b14 / 81 = 0.173$$c2020$$dQ1$$eT1
000095862 592__ $$a1.32$$b2020
000095862 593__ $$aPhysiology (medical)$$c2020$$dQ2
000095862 593__ $$aPhysiology$$c2020$$dQ2
000095862 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095862 700__ $$aPorter, B
000095862 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000095862 700__ $$0(orcid)0000-0002-1927-1762$$aSampedro-Puente, David Adolfo
000095862 700__ $$aFernandez-Bes, Jesús
000095862 700__ $$aSidhu, B
000095862 700__ $$aGould, J
000095862 700__ $$aOrini, M
000095862 700__ $$aBishop, MJ
000095862 700__ $$aHanson, B
000095862 700__ $$aLambiase, P
000095862 700__ $$aRazavi, R
000095862 700__ $$aRinaldi, CA
000095862 700__ $$aGill, JS
000095862 700__ $$aTaggart, P
000095862 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000095862 773__ $$g10 (2020), 1582 [11 pp]$$pFront. physiol.$$tFRONTIERS IN PHYSIOLOGY$$x1664-042X
000095862 8564_ $$s565218$$uhttps://zaguan.unizar.es/record/95862/files/texto_completo.pdf$$yVersión publicada
000095862 8564_ $$s496820$$uhttps://zaguan.unizar.es/record/95862/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095862 909CO $$ooai:zaguan.unizar.es:95862$$particulos$$pdriver
000095862 951__ $$a2021-09-02-08:43:34
000095862 980__ $$aARTICLE