000095880 001__ 95880
000095880 005__ 20210902121704.0
000095880 0247_ $$2doi$$a10.1186/s12886-020-1322-8
000095880 0248_ $$2sideral$$a116800
000095880 037__ $$aART-2020-116800
000095880 041__ $$aeng
000095880 100__ $$0(orcid)0000-0001-5320-7839$$aBambo, M. P.$$uUniversidad de Zaragoza
000095880 245__ $$aDiagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol
000095880 260__ $$c2020
000095880 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095880 5203_ $$aBackground
Bruch membrane opening–minimum rim width (BMO–MRW) assessment offers a new diagnostic use in glaucoma patients of the Glaucoma Module Premium Edition (GMPE) available for the Spectralis optical coherence tomography (OCT) system. The objective of our research was to evaluate the diagnostic benefits of examining BMO–MRW and peripapillary retinal nerve fibre layer (pRNFL) readings acquired with Spectralis OCT to distinguish between healthy and mild glaucoma patients, comparing those readings with the standard pRNFL application. Moreover, we investigated whether using a particular combination of BMO–MRW and pRNFL parameters with a linear discriminant function (LDF) could further enhance glaucoma diagnosis.
Methods
One hundred thirty-six eyes from 136 individuals were incorporated into this observational, prospective cross-sectional study: 68 mild primary open-angle glaucoma (POAG) patients according to the Hodapp-Parrish-Anderson criteria (mean deviation between 0 and?-?6?dB) and 68 healthy control subjects selected by Propensity Score Matching. MRW and pRNFL thickness around the disc (diameters: 3.5?mm, 4.1?mm, and 4.7?mm) were obtained using the BMO–MRW protocol, and pRNFL thickness at 3.5?mm was obtained with the standard glaucoma application. The group data were contrasted. One sample was chosen at random to develop the LDF (teaching set: 34 healthy subjects and 34 POAG patients) using a combination of MRW and pRNFL parameters (acquired with the BMO–MRW protocol); the other sample provided a test of how the LDF performed on an independent group (validating set: 34 healthy subjects and 34 POAG patients). The receiver operating curves (ROCs) were plotted for every measurement and contrasted with the proposed LDF. The OCT parameters with the best area under the receiver operating characteristic curve (AUC) were determined.
Results
Global MRW and pRNFL thicknesses were significantly thinner in the POAG group (p?<? 0.001). The BMO–MRW parameters showed good diagnostic accuracy; the largest AUCs reached 0.875 for the LDF and 0.879 for global RNFL thickness using the standard glaucoma application. There were no statistical differences between the AUCs calculated.
Conclusions
BMO–MRW parameters show a strong capability to differentiate between mild glaucoma and control eyes. Our LDF based on the new BMO–MRW OCT protocol did not perform better than isolated parameters.
000095880 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/MAT2017-83858-C2-2
000095880 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095880 590__ $$a2.209$$b2020
000095880 591__ $$aOPHTHALMOLOGY$$b40 / 62 = 0.645$$c2020$$dQ3$$eT2
000095880 592__ $$a0.877$$b2020
000095880 593__ $$aOphthalmology$$c2020$$dQ2
000095880 593__ $$aMedicine (miscellaneous)$$c2020$$dQ2
000095880 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095880 700__ $$aFuentemilla, E.
000095880 700__ $$0(orcid)0000-0001-8769-3441$$aCameo, B.$$uUniversidad de Zaragoza
000095880 700__ $$0(orcid)0000-0002-4316-1635$$aFuertes, I.$$uUniversidad de Zaragoza
000095880 700__ $$0(orcid)0000-0001-7517-4644$$aFerrandez, B.$$uUniversidad de Zaragoza
000095880 700__ $$0(orcid)0000-0001-8563-3437$$aGüerri, N.$$uUniversidad de Zaragoza
000095880 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000095880 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J. M.$$uUniversidad de Zaragoza
000095880 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L. E.$$uUniversidad de Zaragoza
000095880 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000095880 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000095880 773__ $$g20, 35 (2020), [8 pp]$$pBMC OPHTHALMOLOGY$$tBMC OPHTHALMOLOGY$$x1471-2415
000095880 8564_ $$s929197$$uhttps://zaguan.unizar.es/record/95880/files/texto_completo.pdf$$yVersión publicada
000095880 8564_ $$s51861$$uhttps://zaguan.unizar.es/record/95880/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095880 909CO $$ooai:zaguan.unizar.es:95880$$particulos$$pdriver
000095880 951__ $$a2021-09-02-09:16:17
000095880 980__ $$aARTICLE