000095930 001__ 95930 000095930 005__ 20210902121908.0 000095930 0247_ $$2doi$$a10.3390/ijerph17207653 000095930 0248_ $$2sideral$$a120409 000095930 037__ $$aART-2020-120409 000095930 041__ $$aeng 000095930 100__ $$0(orcid)0000-0001-7293-701X$$aAguilar Palacio, Isabel$$uUniversidad de Zaragoza 000095930 245__ $$aNew Male Users of Lipid-Lowering Drugs for Primary Prevention of Cardiovascular Disease: The Impact of Treatment Persistence on Morbimortality. A Longitudinal Study 000095930 260__ $$c2020 000095930 5060_ $$aAccess copy available to the general public$$fUnrestricted 000095930 5203_ $$aThe objective of this study was to analyse persistence to lipid-lowering drug use for primary prevention of cardiovascular disease (CVD) in a new users cohort, to explore all-cause and cardiovascular related morbidity, comorbidity and mortality in this group and, finally, to study the relationship between persistence and morbimortality. We selected subjects who started lipid-lowering treatment for primary prevention of CVD between 1 January 2010 and 31 December 2017 (N = 1424), and classified them as treatment-persistent or -nonpersistent. Bivariate analyses were performed to compare sociodemographic and clinical variables, morbimortality and time to event between groups. The association between morbidities was explored using comorbidity network analysis. The effect of persistence was analysed using logistic regression and Cox survival analyses. Only 38.7% of users were persistent with treatment. Persistent and nonpersistent users had similar sociodemographic and clinical profiles, although differed in age, smoking status, and glycemia. Comorbidity networks revealed that the number of co-occurring diagnoses was higher in nonpersistent than persistent users. Adjusted analyses indicated a protective effect of treatment persistence, especially against major adverse cardiovascular events (MACE), but this effect was not statistically significant. Observational studies are crucial to characterize real-world effectiveness. 000095930 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-01704 000095930 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000095930 590__ $$a3.39$$b2020 000095930 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b41 / 176 = 0.233$$c2020$$dQ1$$eT1 000095930 591__ $$aENVIRONMENTAL SCIENCES$$b118 / 273 = 0.432$$c2020$$dQ2$$eT2 000095930 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b68 / 203 = 0.335$$c2020$$dQ2$$eT2 000095930 592__ $$a0.747$$b2020 000095930 593__ $$aHealth, Toxicology and Mutagenesis$$c2020$$dQ2 000095930 593__ $$aPublic Health, Environmental and Occupational Health$$c2020$$dQ2 000095930 593__ $$aPollution$$c2020$$dQ2 000095930 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000095930 700__ $$0(orcid)0000-0002-6671-5661$$aRabanaque Hernández, María José$$uUniversidad de Zaragoza 000095930 700__ $$0(orcid)0000-0003-1647-3462$$aMaldonado, Lina$$uUniversidad de Zaragoza 000095930 700__ $$aChaure, Armando 000095930 700__ $$0(orcid)0000-0001-9466-3902$$aAbad-Díez, José María$$uUniversidad de Zaragoza 000095930 700__ $$aLeón-Latre, Montse$$uUniversidad de Zaragoza 000095930 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, José Antonio$$uUniversidad de Zaragoza 000095930 700__ $$0(orcid)0000-0002-7194-8275$$aMalo, Sara$$uUniversidad de Zaragoza 000095930 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000095930 7102_ $$14008$$2623$$aUniversidad de Zaragoza$$bDpto. Estruc.Hª Econ.y Eco.Pb.$$cÁrea Métodos Cuant.Econ.Empres 000095930 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ. 000095930 773__ $$g17, 20 (2020), 7653 [13 pp.]$$pInt. j. environ. res. public health$$tInternational Journal of Environmental Research and Public Health$$x1661-7827 000095930 8564_ $$s1856805$$uhttps://zaguan.unizar.es/record/95930/files/texto_completo.pdf$$yVersión publicada 000095930 8564_ $$s490358$$uhttps://zaguan.unizar.es/record/95930/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000095930 909CO $$ooai:zaguan.unizar.es:95930$$particulos$$pdriver 000095930 951__ $$a2021-09-02-10:40:36 000095930 980__ $$aARTICLE