000095943 001__ 95943
000095943 005__ 20210820090346.0
000095943 0247_ $$2doi$$a10.3390/polym11122060
000095943 0248_ $$2sideral$$a116330
000095943 037__ $$aART-2019-116330
000095943 041__ $$aeng
000095943 100__ $$0(orcid)0000-0003-1391-3725$$aRoche, A.$$uUniversidad de Zaragoza
000095943 245__ $$aPolymeric self-assemblies based on tetra-ortho-substituted azobenzene as visible light responsive nanocarriers
000095943 260__ $$c2019
000095943 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095943 5203_ $$aMost of reported polymeric light-responsive nanocarriers make use of UV light to trigger morphological changes and the subsequent release of encapsulated cargoes. Moving from UV-to visible-responsive units is interesting for the potential biomedical applications of these materials. Herein we report the synthesis by ring opening polymerization (ROP) of a series of amphiphilic diblock copolymers, into which either UV or visible responsive azobenzenes have been introduced via copper(I) catalyzed azide-alkyne cycloaddition (CuAAC). These copolymers are able to self-assemble into spherical micelles or vesicles when dispersed in water. The study of the response of the self-assemblies upon UV (365 nm) or visible (530 or 625 nm) light irradiation has been studied by Transmission Electron Microscopy (TEM), Cryogenic Transmission Electron Microscopy (Cryo-TEM), and Dynamic Light Scattering (DLS) studies. Encapsulation of Nile Red, in micelles and vesicles, and Rhodamine B, in vesicles, and its light-stimulated release has been studied by fluorescence spectroscopy and confocal microscopy. Appreciable morphological changes have been induced with green light, and the subsequent release of encapsulated cargoes upon green light irradiation has been confirmed.
000095943 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E47-17R$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2015-071235
000095943 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095943 590__ $$a3.426$$b2019
000095943 591__ $$aPOLYMER SCIENCE$$b16 / 89 = 0.18$$c2019$$dQ1$$eT1
000095943 592__ $$a0.704$$b2019
000095943 593__ $$aPolymers and Plastics$$c2019$$dQ1
000095943 593__ $$aChemistry (miscellaneous)$$c2019$$dQ2
000095943 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095943 700__ $$0(orcid)0000-0002-0922-5615$$aOriol, L.$$uUniversidad de Zaragoza
000095943 700__ $$0(orcid)0000-0003-1141-5933$$aTejedor, R. M.$$uUniversidad de Zaragoza
000095943 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, M.$$uUniversidad de Zaragoza
000095943 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000095943 773__ $$g11, 12 (2019), 2060 [19 pp]$$pPolymers (Basel)$$tPOLYMERS$$x2073-4360
000095943 8564_ $$s1392361$$uhttps://zaguan.unizar.es/record/95943/files/texto_completo.pdf$$yVersión publicada
000095943 8564_ $$s487699$$uhttps://zaguan.unizar.es/record/95943/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095943 909CO $$ooai:zaguan.unizar.es:95943$$particulos$$pdriver
000095943 951__ $$a2021-08-20-08:38:13
000095943 980__ $$aARTICLE