000095946 001__ 95946
000095946 005__ 20230914083246.0
000095946 0247_ $$2doi$$a10.3390/jcm8122110
000095946 0248_ $$2sideral$$a116342
000095946 037__ $$aART-2019-116342
000095946 041__ $$aeng
000095946 100__ $$0(orcid)0000-0003-0669-777X$$aPerez del Palomar, Amaya$$uUniversidad de Zaragoza
000095946 245__ $$aThe Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders
000095946 260__ $$c2019
000095946 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095946 5203_ $$aOcular surface inflammatory disorder (OSID) is a spectrum of disorders that have features of several etiologies whilst displaying similar phenotypic signs of ocular inflammation. They are complicated disorders with underlying mechanisms related to several autoimmune disorders, such as rheumatoid arthritis (RA), Sjogren's syndrome, and systemic lupus erythematosus (SLE). Current literature shows the involvement of both innate and adaptive arms of the immune system in ocular surface inflammation. The ocular surface contains distinct components of the immune system in the conjunctiva and the cornea. The normal conjunctiva epithelium and sub-epithelial stroma contains resident immune cells, such as T cells, B cells (adaptive), dendritic cells, and macrophages (innate). The relative sterile environment of the cornea is achieved by the tolerogenic properties of dendritic cells in the conjunctiva, the presence of regulatory lymphocytes, and the existence of soluble immunosuppressive factors, such as the transforming growth factor (TGF)-beta and macrophage migration inhibitory factors. With the presence of both innate and adaptive immune system components, it is intriguing to investigate the most important leukocyte population in the ocular surface, which is involved in immune surveillance. Our meta-analysis investigates into this with a focus on both infectious (contact lens wear, corneal graft rejection, Cytomegalovirus, keratitis, scleritis, ocular surgery) and non-infectious (dry eye disease, glaucoma, graft-vs-host disease, Sjogren's syndrome) situations. We have found the predominance of dendritic cells in ocular surface diseases, along with the Th-related cytokines. Our goal is to improve the knowledge of immune cells in OSID and to open new dimensions in the field. The purpose of this study is not to limit ourselves in the ocular system, but to investigate the importance of dendritic cells in the disorders of other mucosal organs (e.g., lungs, gut, uterus). Holistically, we want to investigate if this is a common trend in the initiation of any disease related to the mucosal organs and find a unified therapeutic approach. In addition, we want to show the power of computational approaches to foster a collaboration between computational and biological science.
000095946 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/DPI2016-79302-R
000095946 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095946 590__ $$a3.303$$b2019
000095946 591__ $$aMEDICINE, GENERAL & INTERNAL$$b36 / 165 = 0.218$$c2019$$dQ1$$eT1
000095946 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095946 700__ $$0(orcid)0000-0001-7248-4399$$aMontolio, Alberto$$uUniversidad de Zaragoza
000095946 700__ $$aCegonino, Jose
000095946 700__ $$aDhanda, Sandeep Kumar
000095946 700__ $$aLio, Chit Tong
000095946 700__ $$aBose, Tanima
000095946 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000095946 773__ $$g8, 12 (2019), 2019 [15 pp]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000095946 8564_ $$s591318$$uhttps://zaguan.unizar.es/record/95946/files/texto_completo.pdf$$yVersión publicada
000095946 8564_ $$s457883$$uhttps://zaguan.unizar.es/record/95946/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095946 909CO $$ooai:zaguan.unizar.es:95946$$particulos$$pdriver
000095946 951__ $$a2023-09-13-10:50:15
000095946 980__ $$aARTICLE