000095984 001__ 95984
000095984 005__ 20220425105237.0
000095984 0248_ $$2sideral$$a119718
000095984 037__ $$aART-2020-119718
000095984 041__ $$aeng
000095984 100__ $$aAriza-Gracia, M.A.
000095984 245__ $$aBiomechanically-driven simulations of the MyoRing treatment in subjects with high myopia
000095984 260__ $$c2020
000095984 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095984 5203_ $$aPurpose: Corneal biomechanics is a determinant factor for the outcome of continuous intracorneal segments (MyoRing, Dioptex GmbH). However, implant selection remains driven by optical parameters such as the average central curvature of the cornea (Kmean) and the Spherical Equivalent (SE), while failing to account for the tissue biomechanics or the intraocular pressure (IOP). We hypothesize that biomechanical models and computer simulation can improve the refractive outcomes of the MyoRing treatment.
Methods: Four thousand computer models representing the population of patients who are candidates for a MyoRing treatment have been created using the finite element method. These numerical models accounted for physiologic variability of the anatomical features (anterior and posterior corneal radius of curvature, corneal thickness, axial length and pupil size) and mechanical properties (corneal biomechanics and IOP). Two MyoRing implants were evaluated on these virtual patients (Myoring size: 280 µm; optical zone: 5 and 6 mm; depth: 60%-75%; laser ablated pocket 5 µm). Refractive outcomes obtained with the biomechanical simulation were compared to previous clinical data (Daxer 2017; Rattan 2018).
Results: Population-based simulations were able to reproduce the refractive correction observed clinically; the average post-surgical Kmean was within ± 0.5 D of the data reported by Rattan (Fig.1 a), and the distribution of post-surgical SE closely matched the clinical data from Daxer (Fig.1 b). Moreover, our simulation approach allowed us to determine the clinical parameters having the most important contributions to the refractive outcome. For example, we found that the correction in Kmean is strongly related to the pre-surgical thickness, mechanics, and IOP, while the correction in SE is highly affected by the depth of MyoRing insertion.
Conclusions: Biomechanical modelling is able to predict the refractive outcomes of MyoRing implantations. This approach provides a deeper understanding on the mechanisms underlying continuous intracorneal segments, which can be used to improve implant design and further personalize the treatment procedure.
000095984 536__ $$9info:eu-repo/grantAgreement/EC/H2020/786692/EU/Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking/MIMetiCO$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 786692-MIMetiCO
000095984 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000095984 590__ $$a4.799$$b2020
000095984 591__ $$aOPHTHALMOLOGY$$b8 / 62 = 0.129$$c2020$$dQ1$$eT1
000095984 592__ $$a1.935$$b2020
000095984 593__ $$aCellular and Molecular Neuroscience$$c2020$$dQ1
000095984 593__ $$aSensory Systems$$c2020$$dQ1
000095984 593__ $$aOphthalmology$$c2020$$dQ1
000095984 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095984 700__ $$aFlecha-Lescun, J.$$uUniversidad de Zaragoza
000095984 700__ $$0(orcid)0000-0001-9713-1813$$aCalzada, B.C.$$uUniversidad de Zaragoza
000095984 700__ $$aBuchler, P.
000095984 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000095984 773__ $$g61, 7 (2020), 4722 [3 pp]$$pInvestig. ophthalmol. vis. sci.$$tInvestigative ophthalmology & visual science$$x0146-0404
000095984 85641 $$uhttps://iovs.arvojournals.org/article.aspx?articleid=2769897$$zTexto completo de la revista
000095984 8564_ $$s558356$$uhttps://zaguan.unizar.es/record/95984/files/texto_completo.pdf$$yVersión publicada
000095984 8564_ $$s412539$$uhttps://zaguan.unizar.es/record/95984/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095984 909CO $$ooai:zaguan.unizar.es:95984$$particulos$$pdriver
000095984 951__ $$a2022-04-25-10:39:25
000095984 980__ $$aARTICLE