000095994 001__ 95994
000095994 005__ 20201029141735.0
000095994 0247_ $$2doi$$a10.1371/journal.pone.0214717
000095994 0248_ $$2sideral$$a111580
000095994 037__ $$aART-2019-111580
000095994 041__ $$aeng
000095994 100__ $$aGonzalez-Alvaro, I.
000095994 245__ $$aThe comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity
000095994 260__ $$c2019
000095994 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095994 5203_ $$aObjective
To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria.
Methods
Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy).
Results
Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard.
Conclusion
HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s.
000095994 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00442$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/RD16-0012-0011
000095994 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095994 590__ $$a2.74$$b2019
000095994 591__ $$aMULTIDISCIPLINARY SCIENCES$$b27 / 71 = 0.38$$c2019$$dQ2$$eT2
000095994 592__ $$a1.023$$b2019
000095994 593__ $$aMultidisciplinary$$c2019$$dQ1
000095994 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095994 700__ $$aCastrejon, I.
000095994 700__ $$aCarmona, L.
000095994 700__ $$aDougados, M.
000095994 700__ $$aHuizinga, T.
000095994 700__ $$aAbu Shakra, M.
000095994 700__ $$aAlberts, A.
000095994 700__ $$aLopez, M.A.
000095994 700__ $$aAmital, H.
000095994 700__ $$aAringer, M.
000095994 700__ $$aAslanidis, S.
000095994 700__ $$aBerenbaum, F.
000095994 700__ $$aBijlsma, H.
000095994 700__ $$aGarcia, F.J.B.
000095994 700__ $$aBliddal, H.
000095994 700__ $$aBorofsky, M.
000095994 700__ $$aBrocq, O.
000095994 700__ $$aBuldakov, S.
000095994 700__ $$aCantini, F.
000095994 700__ $$aPerez, L.C.
000095994 700__ $$aChahade, W.
000095994 700__ $$aCiconelli, R.
000095994 700__ $$aCodreanu, C.
000095994 700__ $$aDahlqvist, S.R.
000095994 700__ $$aDamjanov, N.
000095994 700__ $$aDiamantopoulos, A.
000095994 700__ $$aDimdina, L.
000095994 700__ $$aDimic, A.
000095994 700__ $$aDorokhov, A.
000095994 700__ $$aDubikov, A.
000095994 700__ $$aFadienko, G.
000095994 700__ $$aFano, N.
000095994 700__ $$aFerreira, G.
000095994 700__ $$aGabrielli, A.
000095994 700__ $$aGaffney, K.
000095994 700__ $$aGaudin, P.
000095994 700__ $$aGerlag, D.M.
000095994 700__ $$aGerli, R.
000095994 700__ $$aGoncalves, C.R.
000095994 700__ $$aHansen, M.S.
000095994 700__ $$aHanvivadhanakul, P.
000095994 700__ $$aHoili, C.
000095994 700__ $$aHou, A.
000095994 700__ $$aHunter, J.
000095994 700__ $$aIlic, T.
000095994 700__ $$aIonescu, R.
000095994 700__ $$aKaine, J.
000095994 700__ $$aKakurina, N.
000095994 700__ $$aKamalova, R.
000095994 700__ $$aKelly, T.
000095994 700__ $$aKnyazeva, L.
000095994 700__ $$aKrumina, L.
000095994 700__ $$aKurthen, R.
000095994 700__ $$aLagrone, R.P.
000095994 700__ $$aLapadula, G.
000095994 700__ $$aLavrentjevs, V.
000095994 700__ $$aLawson, J.G.
000095994 700__ $$aLazic, Z.
000095994 700__ $$aLejnieks, A.
000095994 700__ $$aLevy, Y.
000095994 700__ $$aLexberg, A.
000095994 700__ $$aMader, R.
000095994 700__ $$aMariette, X.
000095994 700__ $$aMarkovits, D.
000095994 700__ $$aMola, E.M.
000095994 700__ $$aMaugars, Y.
000095994 700__ $$aGuarch, J.M.
000095994 700__ $$aMazurov, V.I.
000095994 700__ $$aMikkelsen, K.
000095994 700__ $$aVergles, J.M.
000095994 700__ $$aNabizadeh, S.
000095994 700__ $$aNanagara, R.
000095994 700__ $$aNasonov, E.L.
000095994 700__ $$aSarabia, F.N.
000095994 700__ $$aNeumann, T.
000095994 700__ $$aNovak, S.
000095994 700__ $$aOlech, E.
000095994 700__ $$aOza, M.
000095994 700__ $$aParan, D.
000095994 700__ $$aParsik, E.
000095994 700__ $$aPegram, S.
000095994 700__ $$aSuarez, M.P.
000095994 700__ $$aPopova, T.
000095994 700__ $$aPuechal, X.
000095994 700__ $$aRaja, N.
000095994 700__ $$aRidley, D.
000095994 700__ $$aRosner, I.
000095994 700__ $$aRubbert-Roth, A.
000095994 700__ $$aRudin, A.
000095994 700__ $$aSaraux, A.
000095994 700__ $$aSaulite-Kandevica, D.
000095994 700__ $$aSettas, L.
000095994 700__ $$aSfikakis, P.
000095994 700__ $$aSheeran, T.
000095994 700__ $$aSizikov, A.
000095994 700__ $$aStamenkovic, D.
000095994 700__ $$aStefanovic, D.
000095994 700__ $$aStolow, J.B.
000095994 700__ $$aTan, A.L.
000095994 700__ $$aTebib, J.
000095994 700__ $$aTishler, M.
000095994 700__ $$aTony, H.P.
000095994 700__ $$aTroum, O.M.
000095994 700__ $$aUaratanawong, S.
000095994 700__ $$aAngulo, E.U.
000095994 700__ $$aValenzuela, G.
000095994 700__ $$avan der Laken, K.
000095994 700__ $$aVan Laar, J.
000095994 700__ $$avan Riel, P.L.C.M.
000095994 700__ $$aVasilopoulos, D.
000095994 700__ $$aVeldi, T.
000095994 700__ $$aVinogradova, I.
000095994 700__ $$aVosse, D.
000095994 700__ $$aWassenberg, S.
000095994 700__ $$aWeidmann, C.
000095994 700__ $$aWeitz, M.
000095994 700__ $$aWollenhaupt, J.
000095994 700__ $$aXavier, R.
000095994 700__ $$aYakupova, S.
000095994 700__ $$aZagar, I.
000095994 700__ $$aZavgorodnaja, T.
000095994 700__ $$aZemerova, E.
000095994 700__ $$aZisman, D.
000095994 700__ $$aZonova, E.
000095994 700__ $$aCamona, L.
000095994 700__ $$aAlcazar, L.A.
000095994 700__ $$ade Miguel, C.A.
000095994 700__ $$aSanchez, J.L.A.
000095994 700__ $$aDiez, A.A.
000095994 700__ $$aCriado, A.B.
000095994 700__ $$aGualda, E.B.
000095994 700__ $$aSerrano, M.A.B.
000095994 700__ $$aAudera, J.B.
000095994 700__ $$aFabregat, J.B.
000095994 700__ $$aHernan, G.B.
000095994 700__ $$aFernandez, N.C.
000095994 700__ $$aCasado, E.
000095994 700__ $$aMendez, L.C.
000095994 700__ $$aCoro, M.C.
000095994 700__ $$aDiaz, J.L.C.
000095994 700__ $$aCuesta, E.
000095994 700__ $$aAreste, J.F.
000095994 700__ $$aGonzalez, M.F.
000095994 700__ $$aIzquierdo, M.G.
000095994 700__ $$aMeijide, J.A.G.
000095994 700__ $$aGomez, M.C.G.
000095994 700__ $$aUbeda, E.G.
000095994 700__ $$aCenteno, E.G.
000095994 700__ $$aVaquero, C.G.
000095994 700__ $$aFernandez, M.J.G.
000095994 700__ $$aGomez, M.L.G.
000095994 700__ $$aHernandez, T.G.
000095994 700__ $$aGonzalez-Alvaro, I.
000095994 700__ $$aGomez, C.G.M.
000095994 700__ $$aDelgado, Y.G.
000095994 700__ $$aMasmitja, J.G.
000095994 700__ $$adel Rio, A.H.
000095994 700__ $$aInstxaurbe, A.R.
000095994 700__ $$aOyarzabal, M.V.I.
000095994 700__ $$aPalop, J.
000095994 700__ $$aMas, A.J.
000095994 700__ $$aNavarro, E.J.
000095994 700__ $$aPadro, M.L.
000095994 700__ $$aLongo, F.J.L.
000095994 700__ $$aSantamaria, E.L.
000095994 700__ $$aManzano, J.M.
000095994 700__ $$aRuiz, F.J.M.
000095994 700__ $$aBernardo, I.M.
000095994 700__ $$aGonzalez, L.M.
000095994 700__ $$aMazzucheli, R.
000095994 700__ $$0(orcid)0000-0001-9303-4995$$aMedrano San Idelfonso, M.$$uUniversidad de Zaragoza
000095994 700__ $$aHernandez, A.N.
000095994 700__ $$aEspanol, A.P.
000095994 700__ $$aCallizo, E.P.
000095994 700__ $$aDonate, J.Q.
000095994 700__ $$aLopez, P.R.
000095994 700__ $$aRedondo, J.R.
000095994 700__ $$aGomez, M.R.
000095994 700__ $$aLopez, M.R.
000095994 700__ $$aPardo, R.R.
000095994 700__ $$aAlvarez, J.S.
000095994 700__ $$aSala, R.S.
000095994 700__ $$aRey, J.S.R.
000095994 700__ $$aMarsa, X.T.
000095994 700__ $$aMartin, M.T.
000095994 700__ $$aMartin, M.C.T.
000095994 700__ $$aGarnica, I.U.
000095994 700__ $$ade Diego, J.P.V.
000095994 700__ $$aValls, M.
000095994 700__ $$aGarcia, V.V.
000095994 700__ $$aMontejo, P.Z.
000095994 700__ $$aTabernero, J.Z.
000095994 700__ $$aBalsa, A.
000095994 700__ $$aSanmarti, R.
000095994 700__ $$aCabezas, J.A.
000095994 700__ $$aCantalejo, M.
000095994 700__ $$aChamizo, E.
000095994 700__ $$aCiruelo, E.
000095994 700__ $$aCorrales, A.
000095994 700__ $$aCruz, A.
000095994 700__ $$aDiaz, C.
000095994 700__ $$aFiter, J.
000095994 700__ $$aFreire, M.M.
000095994 700__ $$aGalindo, M.
000095994 700__ $$ade Vicuna, M.R.G.
000095994 700__ $$aGelman, S.M.
000095994 700__ $$aCrespo, R.G.
000095994 700__ $$aFernandez, C.G.
000095994 700__ $$aFernandez, M.J.G.
000095994 700__ $$aHernandez, T.G.
000095994 700__ $$aGracia, A.
000095994 700__ $$aGranados, J.
000095994 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000095994 773__ $$g14, 4 (2019), e0214717 [19 pp]$$pPLoS One$$tPloS one$$x1932-6203
000095994 8564_ $$s634528$$uhttps://zaguan.unizar.es/record/95994/files/texto_completo.pdf$$yVersión publicada
000095994 8564_ $$s423170$$uhttps://zaguan.unizar.es/record/95994/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000095994 951__ $$a2020-10-29-14:05:34
000095994 980__ $$aARTICLE