000096092 001__ 96092 000096092 005__ 20210902121813.0 000096092 0247_ $$2doi$$a10.1093/ecco-jcc/jjz180 000096092 0248_ $$2sideral$$a118291 000096092 037__ $$aART-2020-118291 000096092 041__ $$aeng 000096092 100__ $$aTorres, J. 000096092 245__ $$aECCO guidelines on therapeutics in Crohn's disease: Medical treatment 000096092 260__ $$c2020 000096092 5060_ $$aAccess copy available to the general public$$fUnrestricted 000096092 5203_ $$aCrohn’s disease [CD] is a chronic inflammatory bowel disease [IBD] that can result in progressive bowel damage and disability1. CD can affect individuals of any age, from children to the elderly, 2, 3 and may cause significant morbidity and impact on quality of life. Up to one-third of patients present with complicated behaviour [strictures, fistula, or abscesses] at diagnosis4. Most patients over time will develop a complication, with roughly 50% of patients requiring surgery within 10 years of diagnosis5-7. As the precise aetiology of CD remains unknown, a curative therapy is not yet available8. Several agents are available for the medical treatment of CD. Medical agents include mesalazine [5-ASA], locally active steroids [such as budesonide], systemic steroids, thiopurines such as azathioprine [AZA] and mercaptopurine [MP], methotrexate [MTX], and biological therapies [such as anti-TNF, anti-integrins, and anti-IL12/23]. The European Crohn’s and Colitis Organisation [ECCO] produces and regularly updates several guidelines aimed at providing evidence-based guidance on critical aspects of IBD care to all healthcare professionals who manage patients with IBD. To provide high-quality evidence-based recommendations on medical and surgical treatment in CD, ECCO decided to develop these guidelines by adopting the GRADE [Grading of Recommendations Assessment, Development, and Evaluation] approach9. GRADE is a systematic process for developing guidelines that addresses how to frame the healthcare questions, summarize the evidence, .. 000096092 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000096092 590__ $$a9.071$$b2020 000096092 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b14 / 92 = 0.152$$c2020$$dQ1$$eT1 000096092 592__ $$a3.277$$b2020 000096092 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000096092 593__ $$aGastroenterology$$c2020$$dQ1 000096092 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion 000096092 700__ $$aBonovas, S. 000096092 700__ $$aDoherty, G. 000096092 700__ $$aKucharzik, T. 000096092 700__ $$aGisbert, J.P. 000096092 700__ $$aRaine, T. 000096092 700__ $$aAdamina, M. 000096092 700__ $$aArmuzzi, A. 000096092 700__ $$aBachmann, O. 000096092 700__ $$aBager, P. 000096092 700__ $$aBiancone, L. 000096092 700__ $$aBokemeyer, B. 000096092 700__ $$aBossuyt, P. 000096092 700__ $$aBurisch, J. 000096092 700__ $$aCollins, P. 000096092 700__ $$aEl-Hussuna, A. 000096092 700__ $$aEllul, P. 000096092 700__ $$aFrei-Lanter, C. 000096092 700__ $$aFurfaro, F. 000096092 700__ $$aGingert, C. 000096092 700__ $$aGionchetti, P. 000096092 700__ $$0(orcid)0000-0003-0076-3529$$aGomollon, F.$$uUniversidad de Zaragoza 000096092 700__ $$aGonzález-Lorenzo, M. 000096092 700__ $$aGordon, H. 000096092 700__ $$aHlavaty, T. 000096092 700__ $$aJuillerat, P. 000096092 700__ $$aKatsanos, K. 000096092 700__ $$aKopylov, U. 000096092 700__ $$aKrustins, E. 000096092 700__ $$aLytras, T. 000096092 700__ $$aMaaser, C. 000096092 700__ $$aMagro, F. 000096092 700__ $$aKenneth Marshall, J. 000096092 700__ $$aMyrelid, P. 000096092 700__ $$aPellino, G. 000096092 700__ $$aRosa, I. 000096092 700__ $$aSabino, J. 000096092 700__ $$aSavarino, E. 000096092 700__ $$aSpinelli, A. 000096092 700__ $$aStassen, L. 000096092 700__ $$aUzzan, M. 000096092 700__ $$aVavricka, S. 000096092 700__ $$aVerstockt, B. 000096092 700__ $$aWarusavitarne, J. 000096092 700__ $$aZmora, O. 000096092 700__ $$aFiorino, G. 000096092 700__ $$aon, behalf, of, the, European, Crohn''s, and, Colitis, Organisation, [ECCO] 000096092 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000096092 773__ $$g14, 1 (2020), 4-22$$pJ. Crohns Colitis$$tJournal of Crohn's & colitis$$x1873-9946 000096092 8564_ $$s607630$$uhttps://zaguan.unizar.es/record/96092/files/texto_completo.pdf$$yPostprint 000096092 8564_ $$s664411$$uhttps://zaguan.unizar.es/record/96092/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000096092 909CO $$ooai:zaguan.unizar.es:96092$$particulos$$pdriver 000096092 951__ $$a2021-09-02-10:02:37 000096092 980__ $$aARTICLE