doi:10.1093/ecco-jcc/jjz180engTorres, J.Bonovas, S.Doherty, G.Kucharzik, T.Gisbert, J.P.Raine, T.Adamina, M.Armuzzi, A.Bachmann, O.Bager, P.Biancone, L.Bokemeyer, B.Bossuyt, P.Burisch, J.Collins, P.El-Hussuna, A.Ellul, P.Frei-Lanter, C.Furfaro, F.Gingert, C.Gionchetti, P.Gomollon, F.González-Lorenzo, M.Gordon, H.Hlavaty, T.Juillerat, P.Katsanos, K.Kopylov, U.Krustins, E.Lytras, T.Maaser, C.Magro, F.Kenneth Marshall, J.Myrelid, P.Pellino, G.Rosa, I.Sabino, J.Savarino, E.Spinelli, A.Stassen, L.Uzzan, M.Vavricka, S.Verstockt, B.Warusavitarne, J.Zmora, O.Fiorino, G.on, behalf, of, the, European, Crohn''s, and, Colitis, Organisation, [ECCO]ECCO guidelines on therapeutics in Crohn's disease: Medical treatmentART-2020-118291Crohn’s disease [CD] is a chronic inflammatory bowel disease [IBD] that can result in progressive bowel damage and disability1. CD can affect individuals of any age, from children to the elderly, 2, 3 and may cause significant morbidity and impact on quality of life. Up to one-third of patients present with complicated behaviour [strictures, fistula, or abscesses] at diagnosis4. Most patients over time will develop a complication, with roughly 50% of patients requiring surgery within 10 years of diagnosis5-7. As the precise aetiology of CD remains unknown, a curative therapy is not yet available8. Several agents are available for the medical treatment of CD. Medical agents include mesalazine [5-ASA], locally active steroids [such as budesonide], systemic steroids, thiopurines such as azathioprine [AZA] and mercaptopurine [MP], methotrexate [MTX], and biological therapies [such as anti-TNF, anti-integrins, and anti-IL12/23]. The European Crohn’s and Colitis Organisation [ECCO] produces and regularly updates several guidelines aimed at providing evidence-based guidance on critical aspects of IBD care to all healthcare professionals who manage patients with IBD. To provide high-quality evidence-based recommendations on medical and surgical treatment in CD, ECCO decided to develop these guidelines by adopting the GRADE [Grading of Recommendations Assessment, Development, and Evaluation] approach9. GRADE is a systematic process for developing guidelines that addresses how to frame the healthcare questions, summarize the evidence, ..2020http://zaguan.unizar.es/record/9609210.1093/ecco-jcc/jjz180http://zaguan.unizar.es/record/96092oai:zaguan.unizar.es:96092Journal of Crohn's & colitis 14, 1 (2020), 4-22All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess