000096115 001__ 96115
000096115 005__ 20240123082600.0
000096115 0247_ $$2doi$$a10.3390/ijms21197331
000096115 0248_ $$2sideral$$a120761
000096115 037__ $$aART-2020-120761
000096115 041__ $$aeng
000096115 100__ $$aAbuobeid, R.
000096115 245__ $$aDietary erythrodiol modifies hepatic transcriptome in mice in a sex and dose-dependent way
000096115 260__ $$c2020
000096115 5060_ $$aAccess copy available to the general public$$fUnrestricted
000096115 5203_ $$aErythrodiol is a terpenic compound found in a large number of plants. To test the hypotheses that its long-term administration may influence hepatic transcriptome and this could be influenced by the presence of APOA1-containing high-density lipoproteins (HDL), Western diets containing 0.01% of erythrodiol (10 mg/kg dose) were provided to Apoe-and Apoa1-deficient mice. Hepatic RNA-sequencing was carried out in male Apoe-deficient mice fed purified Western diets differing in the erythrodiol content. The administration of this compound significantly up-regulated 68 and down-regulated 124 genes at the level of 2-fold change. These genes belonged to detoxification processes, protein metabolism and nucleic acid related metabolites. Gene expression changes of 21 selected transcripts were verified by RT-qPCR. Ccl19-ps2, Cyp2b10, Rbm14-rbm4, Sec61g, Tmem81, Prtn3, Amy2a5, Cyp2b9 and Mup1 showed significant changes by erythrodiol administration. When Cyp2b10, Dmbt1, Cyp2b13, Prtn3 and Cyp2b9 were analyzed in female Apoe-deficient mice, no change was observed. Likewise, no significant variation was observed in Apoa1-or in Apoe-deficient mice receiving doses ranging from 0.5 to 5 mg/kg erythrodiol. Our results give evidence that erythrodiol exerts a hepatic transcriptional role, but this is selective in terms of sex and requires a threshold dose. Furthermore, it requires an APOA1-containing HDL.
000096115 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIIII-FEDER/PID2019-104915RB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FSE/B16-20R$$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012
000096115 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000096115 590__ $$a5.923$$b2020
000096115 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b67 / 296 = 0.226$$c2020$$dQ1$$eT1
000096115 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b49 / 178 = 0.275$$c2020$$dQ2$$eT1
000096115 592__ $$a1.455$$b2020
000096115 593__ $$aCatalysis$$c2020$$dQ1
000096115 593__ $$aComputer Science Applications$$c2020$$dQ1
000096115 593__ $$aInorganic Chemistry$$c2020$$dQ1
000096115 593__ $$aSpectroscopy$$c2020$$dQ1
000096115 593__ $$aMolecular Biology$$c2020$$dQ1
000096115 593__ $$aOrganic Chemistry$$c2020$$dQ1
000096115 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1
000096115 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000096115 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000096115 700__ $$0(orcid)0000-0002-4665-9674$$aHerrera-Marcos, L.
000096115 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, M.A.$$uUniversidad de Zaragoza
000096115 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza
000096115 700__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, R.$$uUniversidad de Zaragoza
000096115 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, J.$$uUniversidad de Zaragoza
000096115 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza
000096115 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000096115 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000096115 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000096115 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000096115 773__ $$g21, 19 (2020), 7331 [21 pp]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000096115 8564_ $$s712979$$uhttps://zaguan.unizar.es/record/96115/files/texto_completo.pdf$$yVersión publicada
000096115 8564_ $$s504629$$uhttps://zaguan.unizar.es/record/96115/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000096115 909CO $$ooai:zaguan.unizar.es:96115$$particulos$$pdriver
000096115 951__ $$a2024-01-23-08:21:28
000096115 980__ $$aARTICLE