000096116 001__ 96116
000096116 005__ 20210902121841.0
000096116 0247_ $$2doi$$a10.1371/journal.pone.0240441
000096116 0248_ $$2sideral$$a120762
000096116 037__ $$aART-2020-120762
000096116 041__ $$aeng
000096116 100__ $$aViladés, E.
000096116 245__ $$aPhysiological changes in retinal layers thicknesses measured with swept source optical coherence tomography
000096116 260__ $$c2020
000096116 5060_ $$aAccess copy available to the general public$$fUnrestricted
000096116 5203_ $$aPurpose
To evaluate the physiological changes related with age of all retinal layers thickness measurements in macular and peripapillary areas in healthy eyes.
Methods
Wide protocol scan (with a field of view of 12x9 cm) from Triton SS-OCT instrument (Topcon Corporation, Japan) was performed 463 heathy eyes from 463 healthy controls. This protocol allows to measure the thickness of the following layers: Retina, Retinal nerve fiber layer (RNFL), Ganglion cell layer (GCL +), GCL++ and choroid. In those layers, mean thickness was compared in four groups of ages: Group 1 (71 healthy subjects aged between 20 and 34 years); Group 2 (65 individuals aged 35–49 years), Group 3 (230 healthy controls aged 50–64 years) and Group 4 (97 healthy subjects aged 65–79 years).
Results
The most significant thinning of all retinal layers occurs particularly in the transition from group 2 to group 3, especially in temporal superior quadrant at RNFL, GCL++ and retinal layers (p=0.001), and temporal superior, temporal inferior, and temporal half in choroid layer (p<0.001). Curiously group 2 when compared with group 1 presents a significant thickening of RNFL in temporal superior quadrant (p = 0.001), inferior (p<0.001) and temporal (p = 0.001) halves, and also in nasal half in choroid layer (p = 0.001).
Conclusions
Excepting the RNFL, which shows a thickening until the third decade of life, the rest of the layers seem to have a physiological progressive thinning. Copyright:
000096116 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/DPI2016-79302R$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/MAT2017-83858-C2-2
000096116 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000096116 590__ $$a3.24$$b2020
000096116 591__ $$aMULTIDISCIPLINARY SCIENCES$$b26 / 73 = 0.356$$c2020$$dQ2$$eT2
000096116 592__ $$a0.99$$b2020
000096116 593__ $$aMultidisciplinary$$c2020$$dQ1
000096116 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000096116 700__ $$0(orcid)0000-0003-0669-777X$$aPerez del Palomar, A.$$uUniversidad de Zaragoza
000096116 700__ $$0(orcid)0000-0002-2967-6747$$aCegoñino, J.$$uUniversidad de Zaragoza
000096116 700__ $$aObis, J.
000096116 700__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.$$uUniversidad de Zaragoza
000096116 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna, E.$$uUniversidad de Zaragoza
000096116 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000096116 700__ $$aCiprés, M.
000096116 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia Martin, E.$$uUniversidad de Zaragoza
000096116 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000096116 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000096116 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000096116 773__ $$g15, 10 October (2020), e0240441 [14 pp]$$pPLoS One$$tPloS one$$x1932-6203
000096116 8564_ $$s669899$$uhttps://zaguan.unizar.es/record/96116/files/texto_completo.pdf$$yVersión publicada
000096116 8564_ $$s406068$$uhttps://zaguan.unizar.es/record/96116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000096116 909CO $$ooai:zaguan.unizar.es:96116$$particulos$$pdriver
000096116 951__ $$a2021-09-02-10:23:33
000096116 980__ $$aARTICLE