96116 20210902121841.0 doi 10.1371/journal.pone.0240441 sideral 120762 ART-2020-120762 eng Viladés, E. Physiological changes in retinal layers thicknesses measured with swept source optical coherence tomography 2020 Access copy available to the general public Unrestricted Purpose To evaluate the physiological changes related with age of all retinal layers thickness measurements in macular and peripapillary areas in healthy eyes. Methods Wide protocol scan (with a field of view of 12x9 cm) from Triton SS-OCT instrument (Topcon Corporation, Japan) was performed 463 heathy eyes from 463 healthy controls. This protocol allows to measure the thickness of the following layers: Retina, Retinal nerve fiber layer (RNFL), Ganglion cell layer (GCL +), GCL++ and choroid. In those layers, mean thickness was compared in four groups of ages: Group 1 (71 healthy subjects aged between 20 and 34 years); Group 2 (65 individuals aged 35–49 years), Group 3 (230 healthy controls aged 50–64 years) and Group 4 (97 healthy subjects aged 65–79 years). Results The most significant thinning of all retinal layers occurs particularly in the transition from group 2 to group 3, especially in temporal superior quadrant at RNFL, GCL++ and retinal layers (p=0.001), and temporal superior, temporal inferior, and temporal half in choroid layer (p<0.001). Curiously group 2 when compared with group 1 presents a significant thickening of RNFL in temporal superior quadrant (p = 0.001), inferior (p<0.001) and temporal (p = 0.001) halves, and also in nasal half in choroid layer (p = 0.001). Conclusions Excepting the RNFL, which shows a thickening until the third decade of life, the rest of the layers seem to have a physiological progressive thinning. Copyright: info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726 info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/DPI2016-79302R info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/MAT2017-83858-C2-2 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.24 2020 MULTIDISCIPLINARY SCIENCES 26 / 73 = 0.356 2020 Q2 T2 0.99 2020 Multidisciplinary 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Perez del Palomar, A. Universidad de Zaragoza (orcid)0000-0003-0669-777X Cegoñino, J. Universidad de Zaragoza (orcid)0000-0002-2967-6747 Obis, J. Satue, M. Universidad de Zaragoza (orcid)0000-0002-1609-5994 Orduna, E. Universidad de Zaragoza (orcid)0000-0003-2710-1875 Pablo, L.E. Universidad de Zaragoza (orcid)0000-0003-2389-8282 Ciprés, M. Garcia Martin, E. Universidad de Zaragoza (orcid)0000-0001-6258-2489 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 15, 10 October (2020), e0240441 [14 pp] PLoS One PloS one 1932-6203 669899 http://zaguan.unizar.es/record/96116/files/texto_completo.pdf Versión publicada 406068 http://zaguan.unizar.es/record/96116/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:96116 articulos driver 2021-09-02-10:23:33 ARTICLE