96164 20210902121854.0 doi 10.3389/fphys.2020.566399 sideral 120727 ART-2020-120727 eng Hernández-Vicente, A. Universidad de Zaragoza (orcid)0000-0001-6025-5070 Heart Rate Variability and Exceptional Longevity 2020 Access copy available to the general public Unrestricted Centenarians are the paradigm of human extreme longevity and healthy aging, because they have postponed, if not avoided, mayor age-related diseases. The purpose of this study was to investigate potential differences in resting heart rate variability (HRV) between young adults, octogenarians, and centenarians and assess whether HRV variables are predictors of all-cause mortality in centenarians. To this end, three groups of participants: young adults (N = 20; 20.6 ± 2.3 years), octogenarians (N = 18; 84.1 ± 2.6 years), and centenarians (N = 17; 101.9 ± 1.9 years) were monitored for 15 min at rest (seated, without moving or talking) to measure RR intervals, from which HRV was evaluated. Our results showed a clear decrease with age in the main parasympathetic HRV variables, as well as in the standard deviation (SD) of the RR series [SD of normal-to-normal interval (SDNN)] and in low frequency (LF) heart rate (HR) oscillations, although differences between octogenarians and centenarians did not reach statistical significance. In 14 centenarians followed until death, only SDNN showed significant correlation (¿ = 0.536; p = 0.048) with survival prognosis. Additionally, SDNN <19 ms was associated with early mortality (=1 year) in centenarians (Hazard Ratio = 5.72). In conclusion, HRV indices reflecting parasympathetic outflow as well as SDNN and LF all present an age-related reduction, which could be representative of a natural exhaustion of allostatic systems related to age. Moreover, low SDNN values (<19 ms) could be associated with early mortality in centenarians. HRV seems to play a role in exceptional longevity, which could be accounted for by centenarians’ exposome. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA-FSE/LMP124-18 info:eu-repo/grantAgreement/ES/DGA-FSE/LMP24-18 info:eu-repo/grantAgreement/ES/DGA-FSE/LMP44-18 info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284 info:eu-repo/grantAgreement/ES/MECD/FPU16-05879 info:eu-repo/grantAgreement/ES/MICIU/PID2019-105674RB-I00 info:eu-repo/grantAgreement/ES/MICIU/RTI2018-097723-B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.566 2020 PHYSIOLOGY 14 / 81 = 0.173 2020 Q1 T1 1.32 2020 Physiology (medical) 2020 Q2 Physiology 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Hernando, D. (orcid)0000-0002-1462-4880 Santos-Lozano, A. Rodríguez-Romo, G. Vicente-Rodríguez, G. Universidad de Zaragoza (orcid)0000-0002-4303-4097 Pueyo, E. Universidad de Zaragoza (orcid)0000-0002-1960-407X Bailón, R. Universidad de Zaragoza (orcid)0000-0003-1272-0550 Garatachea, N. Universidad de Zaragoza (orcid)0000-0001-8374-9081 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 11 (2020), 566399 [9 pp] Front. physiol. FRONTIERS IN PHYSIOLOGY 1664-042X 271377 http://zaguan.unizar.es/record/96164/files/texto_completo.pdf Versión publicada 29197 http://zaguan.unizar.es/record/96164/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:96164 articulos driver 2021-09-02-10:31:33 ARTICLE