96184 20210902121838.0 doi 10.1021/acs.jmedchem.0c00781 sideral 120397 ART-2020-120397 eng Pérez-López, A.M. Bioorthogonal Uncaging of Cytotoxic Paclitaxel through Pd Nanosheet-Hydrogel Frameworks 2020 Access copy available to the general public Unrestricted The promising potential of bioorthogonal catalysis in biomedicine is inspiring incremental efforts to design strategies that regulate drug activity in living systems. To achieve this, it is not only essential to develop customized inactive prodrugs and biocompatible metal catalysts but also the right physical environment for them to interact and enable drug production under spatial and/or temporal control. Toward this goal, here, we report the first inactive precursor of the potent broad-spectrum anticancer drug paclitaxel (a.k.a. Taxol) that is stable in cell culture and labile to Pd catalysts. This new prodrug is effectively uncaged in cancer cell culture by Pd nanosheets captured within agarose and alginate hydrogels, providing a biodegradable catalytic framework to achieve controlled release of one of the most important chemotherapy drugs in medical practice. The compatibility of bioorthogonal catalysis and physical hydrogels opens up new opportunities to administer and modulate the mobility of transition metal catalysts in living environs. info:eu-repo/grantAgreement/EC/H2020/658833/EU/Development of Palladium-Labile Prodrugs for Bioorthogonally-Activated Chemotherapy/ChemoBOOM This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 658833-ChemoBOOM info:eu-repo/grantAgreement/EC/H2020/749299/EU/Integrated drug discovery approach to generate brain-penetrant inhibitors of glioblastoma cell proliferation/BRAINHIB This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 749299-BRAINHIB info:eu-repo/grantAgreement/ES/MICINN/RTI2018-099019-A-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.446 2020 CHEMISTRY, MEDICINAL 3 / 63 = 0.048 2020 Q1 T1 2.009 2020 Molecular Medicine 2020 Q1 Drug Discovery 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rubio-Ruiz, B. Valero, T. Contreras-Montoya, R. Álvarez de Cienfuegos, L. (orcid)0000-0002-6873-5244 Sebastián, Víctor Universidad de Zaragoza (orcid)0000-0002-8701-9745 Santamaría, Jesús Universidad de Zaragoza Unciti-Broceta, A. 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 63, 17 (2020), 9650-9659 J. med. chem. Journal of medicinal chemistry 0022-2623 1447549 http://zaguan.unizar.es/record/96184/files/texto_completo.pdf Versión publicada 88453 http://zaguan.unizar.es/record/96184/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:96184 articulos driver 2021-09-02-10:22:03 ARTICLE