000096213 001__ 96213
000096213 005__ 20210902121846.0
000096213 0247_ $$2doi$$a10.1186/s12711-020-00582-2
000096213 0248_ $$2sideral$$a120746
000096213 037__ $$aART-2020-120746
000096213 041__ $$aeng
000096213 100__ $$aPoyato-Bonilla, J.
000096213 245__ $$aGenetic inbreeding depression load for morphological traits and defects in the Pura Raza Española horse
000096213 260__ $$c2020
000096213 5060_ $$aAccess copy available to the general public$$fUnrestricted
000096213 5203_ $$aBackground: Inbreeding is caused by mating between related individuals and is associated with reduced fitness and performance (inbreeding depression). Several studies have detected heterogeneity in inbreeding depression among founder individuals. Recently, a procedure was developed to predict hidden inbreeding depression load that is associated with founders using the Mendelian sampling of non-founders. The objectives of this study were to: (1) analyse the population structure and general inbreeding, and (2) test this recent approach for predicting hidden inbreeding depression load for four morphological traits and two morphology defects in the Pura Raza Española (PRE) horse breed. Results: The regression coefficients that were calculated between trait performances and inbreeding coefficients demonstrated the existence of inbreeding depression. In total, 58, 772, 533 partial inbreeding coefficients (Fij) were estimated for the whole PRE population (328, 706 horses). We selected the descendants of horses with a Fij = 6.25% that contributed to at least four offspring and for which morphological traits were measured for the subsequent analysis of inbreeding depression load (639 horses). A pedigree was generated with the last five generations (5026 animals) used as the reference population (average inbreeding coefficient of 8.39% and average relatedness coefficient of 10.76%). Heritability estimates ranged from 0.08 (cresty neck) to 0.80 (height at withers), whereas inbreeding depression load ratios ranged from 0.01 (knock knee) to 0.40 (length of shoulder), for an inbreeding coefficient of 10%. Most of the correlations between additive and inbreeding depression load genetic values and correlations between inbreeding depression load genetic values for the different traits were positive or near 0. Conclusions: Although the average inbreeding depression loads presented negative values, a certain percentage of the animals showed neutral or even positive values. Thus, high levels of inbreeding do not always lead to a decrease in mean phenotypic value or an increase in morphological defects. Hence, individual inbreeding depression loads could be used as a tool to select the most appropriate breeding animals. The possibility of selecting horses that have a high genetic value and are more resistant to the deleterious effects of inbreeding should help improve selection outcomes.
000096213 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/AGL2017-84217-P
000096213 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000096213 590__ $$a4.297$$b2020
000096213 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b5 / 63 = 0.079$$c2020$$dQ1$$eT1
000096213 591__ $$aGENETICS & HEREDITY$$b57 / 175 = 0.326$$c2020$$dQ2$$eT1
000096213 592__ $$a1.356$$b2020
000096213 593__ $$aAnimal Science and Zoology$$c2020$$dQ1
000096213 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000096213 593__ $$aGenetics$$c2020$$dQ1
000096213 593__ $$aEcology, Evolution, Behavior and Systematics$$c2020$$dQ1
000096213 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000096213 700__ $$aPerdomo-González, D.I.
000096213 700__ $$aSánchez-Guerrero, M.J.
000096213 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, Luis$$uUniversidad de Zaragoza
000096213 700__ $$aMolina, A.
000096213 700__ $$aCasellas, J.
000096213 700__ $$aValera, M.
000096213 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000096213 773__ $$g52, 1 (2020), 62 [12 pp.]$$pGenet. sel. evol.$$tGENETICS SELECTION EVOLUTION$$x0999-193X
000096213 8564_ $$s1263357$$uhttps://zaguan.unizar.es/record/96213/files/texto_completo.pdf$$yVersión publicada
000096213 8564_ $$s53704$$uhttps://zaguan.unizar.es/record/96213/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000096213 909CO $$ooai:zaguan.unizar.es:96213$$particulos$$pdriver
000096213 951__ $$a2021-09-02-10:27:06
000096213 980__ $$aARTICLE