000096819 001__ 96819
000096819 005__ 20240124152520.0
000096819 0247_ $$2doi$$a10.1016/J.JINORGBIO.2019.110934
000096819 0248_ $$2sideral$$a115733
000096819 037__ $$aART-2020-115733
000096819 041__ $$aeng
000096819 100__ $$0(orcid)0000-0002-6178-4801$$aAsín, Javier
000096819 245__ $$aCognition and behavior in sheep repetitively inoculated with aluminum adjuvant-containing vaccines or aluminum adjuvant only
000096819 260__ $$c2020
000096819 5060_ $$aAccess copy available to the general public$$fUnrestricted
000096819 5203_ $$aSheep health management strategies often include the use of aluminum (Al)-containing vaccines. These products were associated with the appearance of the ovine autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), which included an array of ethological changes in the affected animals. The aim of this pilot study was to investigate cognitive and behavioral changes in sheep subjected to a protocol of repetitive inoculation with Al-containing products. Twenty-one lambs were assigned to three groups (n = 7 each): Control, Adjuvant-only, and Vaccine. Vaccine group was inoculated with commercial Al- hydroxide containing vaccines; Adjuvant-only group received the equivalent dose of Al only (Alhydrogel®), and Control group received Phosphate-buffered saline. Sixteen inoculations were administered within a 349-day period. Ethological changes were studied in late summer (7 inoculations) and mid-winter (16 inoculations). Animals in Vaccine and Adjuvant-only groups exhibited individual and social behavioral changes. Affiliative interactions were significantly reduced, and aggressive interactions and stereotypies increased significantly. They also exhibited a significant increase in excitatory behavior and compulsive eating. There were increased levels of stress biomarkers in these two groups. In general, changes were more pronounced in the Vaccine group than they were in the Adjuvant-only group. Some changes were already significant in summer, after seven inoculations only. This study is the first to describe behavioral changes in sheep after having received repetitive injections of Al-containing products, and may explain some of the clinical signs observed in ovine ASIA syndrome.
000096819 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096172-B-C31$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096172-B-C33$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-2-R
000096819 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000096819 590__ $$a4.155$$b2020
000096819 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b9 / 45 = 0.2$$c2020$$dQ1$$eT1
000096819 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b129 / 296 = 0.436$$c2020$$dQ2$$eT2
000096819 592__ $$a0.694$$b2020
000096819 593__ $$aInorganic Chemistry$$c2020$$dQ2
000096819 593__ $$aBiochemistry$$c2020$$dQ2
000096819 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000096819 700__ $$0(orcid)0000-0001-7012-2095$$aPascual-Alonso, María
000096819 700__ $$0(orcid)0000-0002-9210-6026$$aPinczowski, Pedro
000096819 700__ $$aGimeno, Marina
000096819 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, Marta$$uUniversidad de Zaragoza
000096819 700__ $$0(orcid)0000-0003-3074-5778$$aMuniesa, Ana$$uUniversidad de Zaragoza
000096819 700__ $$ade Pablo-Maiso, Lorena
000096819 700__ $$0(orcid)0000-0002-1204-4356$$ade Blas, Ignacio$$uUniversidad de Zaragoza
000096819 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, Delia$$uUniversidad de Zaragoza
000096819 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, Antonio$$uUniversidad de Zaragoza
000096819 700__ $$ade Andrés, Damián
000096819 700__ $$aReina, Ramsés
000096819 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluís$$uUniversidad de Zaragoza
000096819 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000096819 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000096819 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000096819 773__ $$g203 (2020), 110934 [10 pp.]$$pJ. inorg. biochem.$$tJournal of Inorganic Biochemistry$$x0162-0134
000096819 8564_ $$s4885831$$uhttps://zaguan.unizar.es/record/96819/files/texto_completo.pdf$$yPostprint
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000096819 909CO $$ooai:zaguan.unizar.es:96819$$particulos$$pdriver
000096819 951__ $$a2024-01-24-15:17:00
000096819 980__ $$aARTICLE