96819 20240124152520.0 doi 10.1016/J.JINORGBIO.2019.110934 sideral 115733 ART-2020-115733 eng Asín, Javier (orcid)0000-0002-6178-4801 Cognition and behavior in sheep repetitively inoculated with aluminum adjuvant-containing vaccines or aluminum adjuvant only 2020 Access copy available to the general public Unrestricted Sheep health management strategies often include the use of aluminum (Al)-containing vaccines. These products were associated with the appearance of the ovine autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), which included an array of ethological changes in the affected animals. The aim of this pilot study was to investigate cognitive and behavioral changes in sheep subjected to a protocol of repetitive inoculation with Al-containing products. Twenty-one lambs were assigned to three groups (n = 7 each): Control, Adjuvant-only, and Vaccine. Vaccine group was inoculated with commercial Al- hydroxide containing vaccines; Adjuvant-only group received the equivalent dose of Al only (Alhydrogel¬Æ), and Control group received Phosphate-buffered saline. Sixteen inoculations were administered within a 349-day period. Ethological changes were studied in late summer (7 inoculations) and mid-winter (16 inoculations). Animals in Vaccine and Adjuvant-only groups exhibited individual and social behavioral changes. Affiliative interactions were significantly reduced, and aggressive interactions and stereotypies increased significantly. They also exhibited a significant increase in excitatory behavior and compulsive eating. There were increased levels of stress biomarkers in these two groups. In general, changes were more pronounced in the Vaccine group than they were in the Adjuvant-only group. Some changes were already significant in summer, after seven inoculations only. This study is the first to describe behavioral changes in sheep after having received repetitive injections of Al-containing products, and may explain some of the clinical signs observed in ovine ASIA syndrome. info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096172-B-C31 info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096172-B-C33 info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-1-R info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-2-R info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.155 2020 CHEMISTRY, INORGANIC & NUCLEAR 9 / 45 = 0.2 2020 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 129 / 296 = 0.436 2020 Q2 T2 0.694 2020 Inorganic Chemistry 2020 Q2 Biochemistry 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Pascual-Alonso, María (orcid)0000-0001-7012-2095 Pinczowski, Pedro (orcid)0000-0002-9210-6026 Gimeno, Marina Pérez, Marta Universidad de Zaragoza (orcid)0000-0002-8133-2124 Muniesa, Ana Universidad de Zaragoza (orcid)0000-0003-3074-5778 de Pablo-Maiso, Lorena de Blas, Ignacio Universidad de Zaragoza (orcid)0000-0002-1204-4356 Lacasta, Delia Universidad de Zaragoza (orcid)0000-0002-7822-6646 Fernández, Antonio Universidad de Zaragoza (orcid)0000-0002-2557-4890 de Andrés, Damián Reina, Ramsés Luján, Lluís Universidad de Zaragoza (orcid)0000-0002-2053-9842 1001 025 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Anatom.Anatom.Patológ.Com 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 203 (2020), 110934 [10 pp.] J. inorg. biochem. Journal of Inorganic Biochemistry 0162-0134 4885831 http://zaguan.unizar.es/record/96819/files/texto_completo.pdf Postprint 290493 http://zaguan.unizar.es/record/96819/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:96819 articulos driver 2024-01-24-15:17:00 ARTICLE