000097061 001__ 97061
000097061 005__ 20230519145346.0
000097061 0247_ $$2doi$$a10.1016/j.anpedi.2020.06.019
000097061 0248_ $$2sideral$$a120882
000097061 037__ $$aART-2021-120882
000097061 041__ $$aspa
000097061 100__ $$aFernández Ventureira, V.
000097061 245__ $$aEvaluación del seguimiento de niños con hallazgo de hipertransaminasemia
000097061 260__ $$c2021
000097061 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097061 5203_ $$aIntroduction: Although changes in liver function tests can be non-specific in numerous clinical conditions, they can be the first sign of a potentially serious disease in an asymptomatic patient.
Material and methods: Retrospective cohort study, performed by reviewing the records of children of a reference hospital central laboratory with alanine aminorransferase enzyme (ALT) elevation during a 6 month aleatory period.
Results: 572 blood tests with serum ALT elevation corresponding to 403 patients had been assessed during the period studied. 98 patients were excluded for presenting abnormal liver test before the study period of comorbidity that could produce ALT elevation. The remaining 305 patients, 22.6% were diagnosed with a medical condition during the first blood test that explained the ALT elevation, although only 33.3% of them were followed up until verifying their normalization. Final study sample consists of 236 patients with abnormal liver test without apparent liver disease. Adequate follow-up was found only in 29% of them. From this group, 9 patients (13%) were diagnosed with liver disease. The rest of the sample were not properly monitored. In patients with higher serum ALT levels, follow-up was early and more appropiate.
Conclusions: In our area, most children without apparent liver disease are no properly monitored. Therefore, an opportunity to diagnosis and treat a potential liver disease was lost in a great number of children. All children with unexplainedhypertransaminasaemia must be studied.
000097061 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000097061 590__ $$a2.377$$b2021
000097061 591__ $$aPEDIATRICS$$b77 / 130 = 0.592$$c2021$$dQ3$$eT2
000097061 594__ $$a1.8$$b2021
000097061 592__ $$a0.312$$b2021
000097061 593__ $$aPediatrics, Perinatology and Child Health$$c2021$$dQ3
000097061 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097061 700__ $$aRos Arnal, I.
000097061 700__ $$0(orcid)0000-0002-7985-9912$$aRodríguez Martínez, G.$$uUniversidad de Zaragoza
000097061 700__ $$aGarcía Rodríguez, B.
000097061 700__ $$aGarcía Romero, R.
000097061 700__ $$aUbalde Sainz, E.
000097061 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000097061 773__ $$g94, 6 (2021), 359-365$$pAn. pediatr.$$tAnales de Pediatria$$x1695-4033
000097061 8564_ $$s395185$$uhttps://zaguan.unizar.es/record/97061/files/texto_completo.pdf$$yVersión publicada
000097061 8564_ $$s48255$$uhttps://zaguan.unizar.es/record/97061/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097061 909CO $$ooai:zaguan.unizar.es:97061$$particulos$$pdriver
000097061 951__ $$a2023-05-18-13:21:05
000097061 980__ $$aARTICLE