97061 20230519145346.0 doi 10.1016/j.anpedi.2020.06.019 sideral 120882 ART-2021-120882 spa Fernández Ventureira, V. Evaluación del seguimiento de niños con hallazgo de hipertransaminasemia 2021 Access copy available to the general public Unrestricted Introduction: Although changes in liver function tests can be non-specific in numerous clinical conditions, they can be the first sign of a potentially serious disease in an asymptomatic patient. Material and methods: Retrospective cohort study, performed by reviewing the records of children of a reference hospital central laboratory with alanine aminorransferase enzyme (ALT) elevation during a 6 month aleatory period. Results: 572 blood tests with serum ALT elevation corresponding to 403 patients had been assessed during the period studied. 98 patients were excluded for presenting abnormal liver test before the study period of comorbidity that could produce ALT elevation. The remaining 305 patients, 22.6% were diagnosed with a medical condition during the first blood test that explained the ALT elevation, although only 33.3% of them were followed up until verifying their normalization. Final study sample consists of 236 patients with abnormal liver test without apparent liver disease. Adequate follow-up was found only in 29% of them. From this group, 9 patients (13%) were diagnosed with liver disease. The rest of the sample were not properly monitored. In patients with higher serum ALT levels, follow-up was early and more appropiate. Conclusions: In our area, most children without apparent liver disease are no properly monitored. Therefore, an opportunity to diagnosis and treat a potential liver disease was lost in a great number of children. All children with unexplainedhypertransaminasaemia must be studied. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.377 2021 PEDIATRICS 77 / 130 = 0.592 2021 Q3 T2 0.312 2021 Pediatrics, Perinatology and Child Health 2021 Q3 1.8 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ros Arnal, I. Rodríguez Martínez, G. Universidad de Zaragoza (orcid)0000-0002-7985-9912 García Rodríguez, B. García Romero, R. Ubalde Sainz, E. 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 94, 6 (2021), 359-365 An. pediatr. Anales de Pediatria 1695-4033 395185 http://zaguan.unizar.es/record/97061/files/texto_completo.pdf Versión publicada 48255 http://zaguan.unizar.es/record/97061/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:97061 articulos driver 2023-05-18-13:21:05 ARTICLE