000097124 001__ 97124
000097124 005__ 20210902121909.0
000097124 0247_ $$2doi$$a10.1007/s10856-020-06439-w
000097124 0248_ $$2sideral$$a120901
000097124 037__ $$aART-2020-120901
000097124 041__ $$aeng
000097124 100__ $$aLozano, D.
000097124 245__ $$aZnO-mesoporous glass scaffolds loaded with osteostatin and mesenchymal cells improve bone healing in a rabbit bone defect
000097124 260__ $$c2020
000097124 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097124 5203_ $$aThe use of 3D scaffolds based on mesoporous bioactive glasses (MBG) enhanced with therapeutic ions, biomolecules and cells is emerging as a strategy to improve bone healing. In this paper, the osteogenic capability of ZnO-enriched MBG scaffolds loaded or not with osteostatin (OST) and human mesenchymal stem cells (MSC) was evaluated after implantation in New Zealand rabbits. Cylindrical meso-macroporous scaffolds with composition (mol %) 82.2SiO2–10.3CaO–3.3P2O5–4.2ZnO (4ZN) were obtained by rapid prototyping and then, coated with gelatin for easy handling and potentiating the release of inorganic ions and OST. Bone defects (7.5 mm diameter, 12 mm depth) were drilled in the distal femoral epiphysis and filled with 4ZN, 4ZN + MSC, 4ZN + OST or 4ZN + MSC + OST materials to evaluate and compare their osteogenic features. Rabbits were sacrificed at 3 months extracting the distal third of bone specimens for necropsy, histological, and microtomography (µCT) evaluations. Systems investigated exhibited bone regeneration capability. Thus, trabecular bone volume density (BV/TV) values obtained from µCT showed that the good bone healing capability of 4ZN was significantly improved by the scaffolds coated with OST and MSC. Our findings in vivo suggest the interest of these MBG complete systems to improve bone repair in the clinical practice.
000097124 536__ $$9info:eu-repo/grantAgreement/EC/H2020/694160/EU/polyValent mEsopoRous nanosystem for bone DIseases/VERDI$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 694160-VERDI$$9info:eu-repo/grantAgreement/ES/ISCIII/PI15-00978
000097124 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000097124 590__ $$a3.896$$b2020
000097124 591__ $$aENGINEERING, BIOMEDICAL$$b33 / 90 = 0.367$$c2020$$dQ2$$eT2
000097124 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b22 / 40 = 0.55$$c2020$$dQ3$$eT2
000097124 592__ $$a0.644$$b2020
000097124 593__ $$aBioengineering$$c2020$$dQ2
000097124 593__ $$aBiophysics$$c2020$$dQ2
000097124 593__ $$aBiomedical Engineering$$c2020$$dQ2
000097124 593__ $$aBiomaterials$$c2020$$dQ2
000097124 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097124 700__ $$0(orcid)0000-0002-1563-9136$$aGil-Albarova, J.$$uUniversidad de Zaragoza
000097124 700__ $$aHeras, C.
000097124 700__ $$aSánchez-Salcedo, S.
000097124 700__ $$aGómez-Palacio, V.E.
000097124 700__ $$aGómez-Blasco, A.
000097124 700__ $$aDoadrio, J.C.
000097124 700__ $$aVallet-Regí, M.
000097124 700__ $$aSalinas, A.J.
000097124 7102_ $$11013$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Traumatología y Ortopedia
000097124 773__ $$g31, 11 (2020), 100 [11 pp.]$$pJ. mater. sci., Mater. med.$$tJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE$$x0957-4530
000097124 8564_ $$s5011938$$uhttps://zaguan.unizar.es/record/97124/files/texto_completo.pdf$$yVersión publicada
000097124 8564_ $$s63111$$uhttps://zaguan.unizar.es/record/97124/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097124 909CO $$ooai:zaguan.unizar.es:97124$$particulos$$pdriver
000097124 951__ $$a2021-09-02-10:41:21
000097124 980__ $$aARTICLE