97124 20260418110654.0 doi 10.1007/s10856-020-06439-w sideral 120901 ART-2020-120901 eng Lozano, D. ZnO-mesoporous glass scaffolds loaded with osteostatin and mesenchymal cells improve bone healing in a rabbit bone defect 2020 Access copy available to the general public Unrestricted The use of 3D scaffolds based on mesoporous bioactive glasses (MBG) enhanced with therapeutic ions, biomolecules and cells is emerging as a strategy to improve bone healing. In this paper, the osteogenic capability of ZnO-enriched MBG scaffolds loaded or not with osteostatin (OST) and human mesenchymal stem cells (MSC) was evaluated after implantation in New Zealand rabbits. Cylindrical meso-macroporous scaffolds with composition (mol %) 82.2SiO2–10.3CaO–3.3P2O5–4.2ZnO (4ZN) were obtained by rapid prototyping and then, coated with gelatin for easy handling and potentiating the release of inorganic ions and OST. Bone defects (7.5 mm diameter, 12 mm depth) were drilled in the distal femoral epiphysis and filled with 4ZN, 4ZN + MSC, 4ZN + OST or 4ZN + MSC + OST materials to evaluate and compare their osteogenic features. Rabbits were sacrificed at 3 months extracting the distal third of bone specimens for necropsy, histological, and microtomography (µCT) evaluations. Systems investigated exhibited bone regeneration capability. Thus, trabecular bone volume density (BV/TV) values obtained from µCT showed that the good bone healing capability of 4ZN was significantly improved by the scaffolds coated with OST and MSC. Our findings in vivo suggest the interest of these MBG complete systems to improve bone repair in the clinical practice. info:eu-repo/grantAgreement/EC/H2020/694160/EU/polyValent mEsopoRous nanosystem for bone DIseases/VERDI This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 694160-VERDI info:eu-repo/grantAgreement/ES/ISCIII/PI15-00978 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.896 2020 ENGINEERING, BIOMEDICAL 33 / 89 = 0.371 2020 Q2 T2 MATERIALS SCIENCE, BIOMATERIALS 22 / 40 = 0.55 2020 Q3 T2 0.644 2020 Bioengineering 2020 Q2 Biophysics 2020 Q2 Biomedical Engineering 2020 Q2 Biomaterials 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gil-Albarova, J. Universidad de Zaragoza (orcid)0000-0002-1563-9136 Heras, C. Sánchez-Salcedo, S. Gómez-Palacio, V.E. Gómez-Blasco, A. Doadrio, J.C. Vallet-Regí, M. Salinas, A.J. 1013 830 Universidad de Zaragoza Dpto. Cirugía Área Traumatología y Ortopedia 31, 11 (2020), 100 [11 pp.] J. mater. sci., Mater. med. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 0957-4530 4969846 http://zaguan.unizar.es/record/97124/files/texto_completo.pdf Versión publicada 1980708 http://zaguan.unizar.es/record/97124/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:97124 articulos driver 2026-04-18-11:05:02 ARTICLE