000097142 001__ 97142
000097142 005__ 20230914083256.0
000097142 0247_ $$2doi$$a10.1186/s40359-020-00489-z
000097142 0248_ $$2sideral$$a121116
000097142 037__ $$aART-2020-121116
000097142 041__ $$aeng
000097142 100__ $$aViñolas, N.N.
000097142 245__ $$aAssessment of the psychosocial and economic impact according to sex in non-small cell lung cancer patients: an exploratory longitudinal study
000097142 260__ $$c2020
000097142 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097142 5203_ $$aBackground: Little is known about the impact of sex on lung cancer patients from the psychological, economic and social perspectives. This study was designed to explore the psychosocial and economic impact according to sex of metastatic non-small cell lung cancer (mNSCLC) in patients and caregivers.
Methods: Exploratory study of two cohorts of patients starting first-line treatment for mNSCLC. The following questionnaires were administered at baseline, 4 months later and following the first and second disease progression: APGAR, relationship impact scale, DUKE-UNC scale, economic impact in patients and caregiver, and Zarit scale. It was planned to include 1250 patients to get an 80% possibility of detecting as significant (p < 0.05) effect sizes less than 0.19 between men and women. Univariate comparisons were made between the tests applied to men and women. Overall survival was estimated with Kaplan–Meier method. Cox analyses were done to estimate hazard ratios (HRs) with 95% CI.
Results: 333 patients were included. Most families reported to continue being functional despite the lung cancer diagnosis. Regardless of sex, they did not perceive changes in their partner relationship. Most patients felt their social support was normal. Roughly 25% of people reported a worsening in their economic situation, without remarkable differences by sex. Statistically significant differences were found between both groups regarding the caregiver’s relationship to the patient (more parents were the caregiver in females than in males, p < 0.0001) and the caregiver’s employment situation (more employed caregivers in females) (p < 0.0001). Most caregivers of both sexes considered that taking care of their relative did not pose a significant burden.
Conclusions: This study provides a preliminary insight into sex-related characteristics in the management of advanced NSCLC and its impact on the emotional, social and economic burden of patients and their caregivers, and recall the high priority of researching in cancer from a sex perspective. Nevertheless, due to the low recruitment rate and the relevant loss of patients during the follow-up, it was difficult to find differences by sex.
Trial registration: ClinicalTrials.gov identifier: NCT02336061. Ethics committee: Comité Ético de Investigación Clínica del Hospital Clínic de Barcelona, Spain. Reference number: HCB/2014/0705.
000097142 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097142 592__ $$a0.804$$b2020
000097142 593__ $$aPsychology (miscellaneous)$$c2020$$dQ2
000097142 593__ $$aMedicine (miscellaneous)$$c2020$$dQ2
000097142 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097142 700__ $$aGarcia-Campelo, R.
000097142 700__ $$aMajem, M.
000097142 700__ $$aCarcereny, E.
000097142 700__ $$aIsla, D.
000097142 700__ $$aGonzalez-Larriba, J.L.
000097142 700__ $$aCoves, J.
000097142 700__ $$aDe-Castro, J.
000097142 700__ $$aDomine, M.
000097142 700__ $$aLianes, P.
000097142 700__ $$0(orcid)0000-0002-3662-7660$$aArtal, A.$$uUniversidad de Zaragoza
000097142 700__ $$aRemon, J.
000097142 700__ $$aFelip, E.
000097142 700__ $$aGarrido, P.
000097142 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000097142 773__ $$g8, 1 (2020), 123 [9 pp]$$tBMC Psychology$$x2050-7283
000097142 8564_ $$s923965$$uhttps://zaguan.unizar.es/record/97142/files/texto_completo.pdf$$yVersión publicada
000097142 8564_ $$s47026$$uhttps://zaguan.unizar.es/record/97142/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097142 909CO $$ooai:zaguan.unizar.es:97142$$particulos$$pdriver
000097142 951__ $$a2023-09-13-10:51:50
000097142 980__ $$aARTICLE