000097146 001__ 97146 000097146 005__ 20230622083314.0 000097146 0247_ $$2doi$$a10.1039/d0tb01398f 000097146 0248_ $$2sideral$$a121120 000097146 037__ $$aART-2020-121120 000097146 041__ $$aeng 000097146 100__ $$aNeves Borgheti-Cardoso, L. 000097146 245__ $$aPromising nanomaterials in the fight against malaria 000097146 260__ $$c2020 000097146 5060_ $$aAccess copy available to the general public$$fUnrestricted 000097146 5203_ $$aFor more than one hundred years, several treatments against malaria have been proposed but they have systematically failed, mainly due to the occurrence of drug resistance in part resulting from the exposure of the parasite to low drug doses. Several factors are behind this problem, including (i) the formidable barrier imposed by the Plasmodium life cycle with intracellular localization of parasites in hepatocytes and red blood cells, (ii) the adverse fluidic conditions encountered in the blood circulation that affect the interaction of molecular components with target cells, and (iii) the unfavorable physicochemical characteristics of most antimalarial drugs, which have an amphiphilic character and can be widely distributed into body tissues after administration and rapidly metabolized in the liver. To surpass these drawbacks, rather than focusing all efforts on discovering new drugs whose efficacy is quickly decreased by the parasite''s evolution of resistance, the development of effective drug delivery carriers is a promising strategy. Nanomaterials have been investigated for their capacity to effectively deliver antimalarial drugs at local doses sufficiently high to kill the parasites and avoid drug resistance evolution, while maintaining a low overall dose to prevent undesirable toxic side effects. In recent years, several nanostructured systems such as liposomes, polymeric nanoparticles or dendrimers have been shown to be capable of improving the efficacy of antimalarial therapies. In this respect, nanomaterials are a promising drug delivery vehicle and can be used in therapeutic strategies designed to fight the parasite both in humans and in the mosquito vector of the disease. The chemical analyses of these nanomaterials are essential for the proposal and development of effective anti-malaria therapies. This review is intended to analyze the application of nanomaterials to improve the drug efficacy on different stages of the malaria parasites in both the human and mosquito hosts. This journal is 000097146 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E47-20R$$9info:eu-repo/grantAgreement/EC/FP7/321570/EU/EUROpean network for transnational collaborative RTD projects in the field of NANOMEDicine/EURONANOMED II$$9info:eu-repo/grantAgreement/EC/H2020/712754/EU/Postdoctoral Programme in Bioengineering Excellence Scientific Training/BEST$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 712754-BEST$$9info:eu-repo/grantAgreement/ES/MCIU/BES-2016-078774$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/CTQ2017-90596-REDT$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/PCIN-2017-100$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/PGC2018-093761-B-C31$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/PGC2018-097583-B-I00$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/RTI2018-094579-B-I00$$9info:eu-repo/grantAgreement/ES/MICINN/CEX2018-000806-S 000097146 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000097146 590__ $$a6.331$$b2020 000097146 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b12 / 40 = 0.3$$c2020$$dQ2$$eT1 000097146 592__ $$a1.316$$b2020 000097146 593__ $$aBiomedical Engineering$$c2020$$dQ1 000097146 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000097146 593__ $$aMaterials Science (miscellaneous)$$c2020$$dQ1 000097146 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1 000097146 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000097146 700__ $$0(orcid)0000-0003-0063-9456$$aSan Anselmo, M.$$uUniversidad de Zaragoza 000097146 700__ $$aLantero, E. 000097146 700__ $$0(orcid)0000-0001-6584-6603$$aLancelot, A. 000097146 700__ $$0(orcid)0000-0001-9866-6633$$aSerrano, J.L.$$uUniversidad de Zaragoza 000097146 700__ $$0(orcid)0000-0003-3109-4284$$aHernández-Ainsa, S.$$uUniversidad de Zaragoza 000097146 700__ $$aFernàndez-Busquets, X. 000097146 700__ $$0(orcid)0000-0001-7091-077X$$aSierra, T.$$uUniversidad de Zaragoza 000097146 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000097146 773__ $$g8, 41 (2020), 9428-9448$$pJ. mater. chem. B$$tJournal of Materials Chemistry B$$x2050-750X 000097146 8564_ $$s1978136$$uhttps://zaguan.unizar.es/record/97146/files/texto_completo.pdf$$yVersión publicada 000097146 8564_ $$s64679$$uhttps://zaguan.unizar.es/record/97146/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000097146 909CO $$ooai:zaguan.unizar.es:97146$$particulos$$pdriver 000097146 951__ $$a2023-06-21-15:01:06 000097146 980__ $$aARTICLE