97169 20230914083252.0 doi 10.3390/pathogens9110928 sideral 121080 ART-2020-121080 eng Mullbacher, A. SARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity 2020 Access copy available to the general public Unrestricted Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells. info:eu-repo/grantAgreement/ES/DGA-FEDER/B29-17R info:eu-repo/grantAgreement/ES/ISCIII/Fondo-COVID19 info:eu-repo/grantAgreement/ES/MCIU-AEI/SAF2017-83120-C2-1-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.492 2020 MICROBIOLOGY 67 / 135 = 0.496 2020 Q2 T2 0.983 2020 Immunology and Allergy 2020 Q2 Molecular Biology 2020 Q2 Microbiology (medical) 2020 Q2 Infectious Diseases 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pardo, J. Universidad de Zaragoza (orcid)0000-0003-0154-0730 Furuya, Y. 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 9, 11 (2020), 928 [5 pp] Pathogens Pathogens 2076-0817 129699 http://zaguan.unizar.es/record/97169/files/texto_completo.pdf Versión publicada 511925 http://zaguan.unizar.es/record/97169/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:97169 articulos driver 2023-09-13-10:51:08 ARTICLE