97189 20230323131625.0 doi 10.3389/fphys.2020.598314 sideral 121101 ART-2020-121101 eng Chauhan, V.S. Commentary: Increased Beat-to-Beat Variability of T-Wave Heterogeneity Measured From Standard 12-Lead Electrocardiogram Is Associated With Sudden Cardiac Death: A Case-Control Study 2020 Access copy available to the general public Unrestricted The electrocardiogram (ECG) reflects the electrical activity within the heart. Following the discovery of the small electrical signals in the human heart, the Dutch scientist Willem Einthoven developed sensitive methods for detecting them and recognized their clinical implications (Kligfield, 2002). For his contributions Willem Einthoven, whose scientific roots originated from the Utrecht physiology department (Einthoven, 1885), was awarded the Nobel Prize in 1924. Since then, many enigmas of the ECG have been solved and its intricate information carries valuable clues for clinical decision making. In vivo mapping studies have established that spatial heterogeneity in repolarization is a requisite for re-entrant ventricular arrhythmias by effecting unidirectional conduction block. Important modulators of spatial heterogeneity of repolarization include autonomic tone, ischemia, heart rate and premature or ectopic beats, which can produce temporal heterogeneity in the order of seconds, minutes, or hours depending on their time-constants. In the contemporary era of dynamic surface electrocardiography, a formidable challenge is quantifying spatiotemporal repolarization heterogeneity with sufficient fidelity to image the arrhythmogenic myocardial substrate and thereby provide indices for a patient’s risk of arrhythmic death (Laguna et al., 2016). Hekkanen et al. (2020) performed a large case-control study of 200 victims... info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.566 2020 PHYSIOLOGY 14 / 81 = 0.173 2020 Q1 T1 1.32 2020 Physiology (medical) 2020 Q2 Physiology 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martínez, J.P. Universidad de Zaragoza (orcid)0000-0002-7503-3339 van der Heyden, M.A.G. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 11 (2020), 598314 [3 pp] Front. physiol. FRONTIERS IN PHYSIOLOGY 1664-042X 74775 http://zaguan.unizar.es/record/97189/files/texto_completo.pdf Versión publicada 29066 http://zaguan.unizar.es/record/97189/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:97189 articulos driver 2023-03-23-12:57:33 ARTICLE