000097207 001__ 97207 000097207 005__ 20210902121911.0 000097207 0247_ $$2doi$$a10.1017/S2045796020000876 000097207 0248_ $$2sideral$$a121260 000097207 037__ $$aART-2020-121260 000097207 041__ $$aeng 000097207 100__ $$aBae, J.B. 000097207 245__ $$aParity and the risk of incident dementia: a COSMIC study 000097207 260__ $$c2020 000097207 5060_ $$aAccess copy available to the general public$$fUnrestricted 000097207 5203_ $$aAIMS: To investigate the association between parity and the risk of incident dementia in women. METHODS: We pooled baseline and follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies from four European and two Asian countries. We investigated the association between parity and incident dementia using Cox proportional hazards regression models adjusted for age, educational level, hypertension, diabetes mellitus and cohort, with additional analysis by dementia subtype (Alzheimer dementia (AD) and non-Alzheimer dementia (NAD)). RESULTS: Of 9756 women dementia-free at baseline, 7010 completed one or more follow-up assessments. The mean follow-up duration was 5.4 ± 3.1 years and dementia developed in 550 participants. The number of parities was associated with the risk of incident dementia (hazard ratio (HR) = 1.07, 95% confidence interval (CI) = 1.02-1.13). Grand multiparity (five or more parities) increased the risk of dementia by 30% compared to 1-4 parities (HR = 1.30, 95% CI = 1.02-1.67). The risk of NAD increased by 12% for every parity (HR = 1.12, 95% CI = 1.02-1.23) and by 60% for grand multiparity (HR = 1.60, 95% CI = 1.00-2.55), but the risk of AD was not significantly associated with parity. CONCLUSIONS: Grand multiparity is a significant risk factor for dementia in women. This may have particularly important implications for women in low and middle-income countries where the fertility rate and prevalence of grand multiparity are high. 000097207 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Group 19$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103 000097207 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/ 000097207 590__ $$a6.892$$b2020 000097207 591__ $$aPSYCHIATRY$$b11 / 142 = 0.077$$c2020$$dQ1$$eT1 000097207 591__ $$aPSYCHIATRY$$b18 / 155 = 0.116$$c2020$$dQ1$$eT1 000097207 592__ $$a1.718$$b2020 000097207 593__ $$aEpidemiology$$c2020$$dQ1 000097207 593__ $$aPublic Health, Environmental and Occupational Health$$c2020$$dQ1 000097207 593__ $$aPsychiatry and Mental Health$$c2020$$dQ1 000097207 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000097207 700__ $$aLipnicki, D.M. 000097207 700__ $$aHan, J.W. 000097207 700__ $$aSachdev, P.S. 000097207 700__ $$aKim, T.H. 000097207 700__ $$aKwak, K.P. 000097207 700__ $$aKim, B.J. 000097207 700__ $$aKim, S.G. 000097207 700__ $$aKim, J.L. 000097207 700__ $$aMoon, S.W. 000097207 700__ $$aPark, J.H. 000097207 700__ $$aRyu, S.H. 000097207 700__ $$aYoun, J.C. 000097207 700__ $$aLee, D.Y. 000097207 700__ $$aLee, D.W. 000097207 700__ $$aLee, S.B. 000097207 700__ $$aLee, J.J. 000097207 700__ $$aJhoo, J.H. 000097207 700__ $$aSkoog, I. 000097207 700__ $$aNajar, J. 000097207 700__ $$aSterner, T.R. 000097207 700__ $$aScarmeas, N. 000097207 700__ $$aYannakoulia, M. 000097207 700__ $$aDardiotis, E. 000097207 700__ $$aRiedel-Heller, S. 000097207 700__ $$aRoehr, S. 000097207 700__ $$aPabst, A. 000097207 700__ $$aDing, D. 000097207 700__ $$aZhao, Q. 000097207 700__ $$aLiang, X. 000097207 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza 000097207 700__ $$0(orcid)0000-0003-2284-7862$$aDe-la-Cámara, C.$$uUniversidad de Zaragoza 000097207 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza 000097207 700__ $$aKim, K.W. 000097207 700__ $$afor, Cohort, Studies, of, Memory, in, an, International, Consortium, (COSMIC) 000097207 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000097207 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ. 000097207 773__ $$g29 (2020), e176 [7 pp]$$pEpidemiol. psychiatr. sci.$$tEpidemiology and psychiatric sciences$$x2045-7960 000097207 8564_ $$s149057$$uhttps://zaguan.unizar.es/record/97207/files/texto_completo.pdf$$yVersión publicada 000097207 8564_ $$s59942$$uhttps://zaguan.unizar.es/record/97207/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000097207 909CO $$ooai:zaguan.unizar.es:97207$$particulos$$pdriver 000097207 951__ $$a2021-09-02-10:42:04 000097207 980__ $$aARTICLE