000097219 001__ 97219
000097219 005__ 20220511133123.0
000097219 0247_ $$2doi$$a10.1080/17435390.2020.1818325
000097219 0248_ $$2sideral$$a120988
000097219 037__ $$aART-2020-120988
000097219 041__ $$aeng
000097219 100__ $$aCabellos, J.
000097219 245__ $$aShort-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice
000097219 260__ $$c2020
000097219 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097219 5203_ $$aIn this study, two sets of methyl-coated non-porous and mesoporous amorphous silica materials of two target sizes (100 and 300 nm; 10–844 m2/g) were used to investigate the potential role of specific surface area (SSA) and porosity on the oral toxicity in mice. Female Swiss mice were administered by oral gavage for 5 consecutive days. Two silica dose levels (100 and 1000 mg/kg b.w.) were tested for all four materials. All dispersions were characterized by transmission electron microscopy (TEM) and Nanoparticle tracking analysis (NTA). Batch dispersions of porous silica were rather unstable due to agglomeration. Animals were sacrificed one day after the last administration or after a three-week recovery period. No relevant toxicological effects were induced by any of the silica materials tested, as evaluated by body weight, gross pathology, relative organ weights (liver, spleen, kidneys), hematology, blood biochemistry, genotoxicity (Comet assay in jejunum cells and micronucleus test in peripheral blood erythrocytes), liver and small intestine histopathology, and intestinal inflammation. The presence of silica particles in the intestine was evaluated by a hyperspectral imaging microscopy system (CytoViva) using histological samples of jejunum tissue. Silica spectral signatures were found in jejunum samples with all the treatments, but only statistically significant in one of the treatment groups.
000097219 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000097219 590__ $$a5.913$$b2020
000097219 591__ $$aTOXICOLOGY$$b10 / 93 = 0.108$$c2020$$dQ1$$eT1
000097219 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b39 / 106 = 0.368$$c2020$$dQ2$$eT2
000097219 592__ $$a1.175$$b2020
000097219 593__ $$aBiomedical Engineering$$c2020$$dQ1
000097219 593__ $$aToxicology$$c2020$$dQ1
000097219 593__ $$aNanoscience and Nanotechnology$$c2020$$dQ1
000097219 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097219 700__ $$aGimeno-Benito, I.
000097219 700__ $$0(orcid)0000-0003-2936-242X$$aCatalán, J.$$uUniversidad de Zaragoza
000097219 700__ $$aLindberg, H.K.
000097219 700__ $$aVales, G.
000097219 700__ $$aFernandez-Rosas, E.
000097219 700__ $$aGhemis, R.
000097219 700__ $$aJensen, K.A.
000097219 700__ $$aAtluri, R.
000097219 700__ $$aVázquez-Campos, S.
000097219 700__ $$aJaner, G.
000097219 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000097219 773__ $$g14, 10 (2020), 1324-1341$$pNanotoxicology$$tNanotoxicology$$x1743-5390
000097219 8564_ $$s2574334$$uhttps://zaguan.unizar.es/record/97219/files/texto_completo.pdf$$yVersión publicada
000097219 8564_ $$s225298$$uhttps://zaguan.unizar.es/record/97219/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097219 909CO $$ooai:zaguan.unizar.es:97219$$particulos$$pdriver
000097219 951__ $$a2022-05-11-13:13:05
000097219 980__ $$aARTICLE