000097244 001__ 97244
000097244 005__ 20210902121845.0
000097244 0247_ $$2doi$$a10.1109/ACCESS.2020.3031471
000097244 0248_ $$2sideral$$a120946
000097244 037__ $$aART-2020-120946
000097244 041__ $$aeng
000097244 100__ $$aRodrigues, A.S.
000097244 245__ $$aNoninvasive Monitoring of Potassium Fluctuations During the Long Interdialytic Interval
000097244 260__ $$c2020
000097244 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097244 5203_ $$aHemodialysis patients are susceptible to life-threatening arrhythmias whose incidence is markedly higher during the long interdialytic interval due to electrolyte Fluctuations. Noninvasive monitoring of electrolyte fluctuations, particularly those of potassium, would enable restoring electrolyte balance before the onset of arrhythmias. This study investigates the feasibility of continuous long-term monitoring of potassium fluctuations using a single-lead electrocardiogram. We evaluate patient-specific T-wave morphology changes in the electrocardiogram using two descriptors: 1) a model-based descriptor, theta(delta) developed to account for overall morphology changes, and 2) the currently available descriptor, TSA, sensitive to potassium levels in single-lead electrocardiograms. Electrocardiograms of 15 hemodialysis patients with pre-existent cardiac diseases were acquired continuously over the long interdialytic interval along with blood samples at predetermined time instants. Results reveal that theta(delta) and TSA respond concordantly with potassium levels, and reacts to potassium lowering medication. The overlapping index of the daily distributions of theta(delta) and TSA are moderately correlated with changes in potassium levels (r D 0 :56 and r D 0 :57, respectively). theta(delta) exhibits circadian variation, peaking amidst morning and decreasing until evening. theta(delta) appears to be less affected by motion-induced noise, which is preferable for ambulatory monitoring. Although long-term monitoring of potassium fluctuations is feasible even in complicated hemodialysis patients, the presence of concomitant electrolyte (calcium and bicarbonate) imbalances should be accounted for since it can hamper a reliable estimation. Considering that intradialytic T-wave morphologies may differ from the ones manifested between hemodialysis sessions, future studies should also strive to collect blood samples outside of hemodialysis to improve electrolyte estimation methods.
000097244 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097244 590__ $$a3.367$$b2020
000097244 591__ $$aCOMPUTER SCIENCE, INFORMATION SYSTEMS$$b65 / 162 = 0.401$$c2020$$dQ2$$eT2
000097244 591__ $$aTELECOMMUNICATIONS$$b36 / 91 = 0.396$$c2020$$dQ2$$eT2
000097244 591__ $$aENGINEERING, ELECTRICAL & ELECTRONIC$$b94 / 273 = 0.344$$c2020$$dQ2$$eT2
000097244 592__ $$a0.586$$b2020
000097244 593__ $$aComputer Science (miscellaneous)$$c2020$$dQ1
000097244 593__ $$aMaterials Science (miscellaneous)$$c2020$$dQ1
000097244 593__ $$aEngineering (miscellaneous)$$c2020$$dQ1
000097244 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097244 700__ $$aPetrenas, A.
000097244 700__ $$aPaliakaite, B.
000097244 700__ $$aKusleikaite-Pere, N.
000097244 700__ $$aJarusevicius, G.
000097244 700__ $$aBumblyte, I.A.
000097244 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, P.$$uUniversidad de Zaragoza
000097244 700__ $$aMarozas, V.
000097244 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000097244 773__ $$g8 (2020), 188488-188502$$pIEEE Access$$tIEEE Access$$x2169-3536
000097244 8564_ $$s2926014$$uhttps://zaguan.unizar.es/record/97244/files/texto_completo.pdf$$yVersión publicada
000097244 8564_ $$s522854$$uhttps://zaguan.unizar.es/record/97244/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097244 909CO $$ooai:zaguan.unizar.es:97244$$particulos$$pdriver
000097244 951__ $$a2021-09-02-10:26:34
000097244 980__ $$aARTICLE