Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged &lt;50 years

Jara-Palomares, L.; Mellado, M.; Kigitovica, D.; Gutiérrez-González, S.; Salgado, E.; Gómez, V.; Bascuñana, J.; Iglesias, M.; Mazzolai, L.; Gutiérrez, P.; Amado, C.; Reyes, R.L.; Joya, M.D.; Demelo, P.; Vandenbriele, C.; Font, L.; Adela Rodríguez-Hernández, A.; Vidal, G.; Vázquez, F.J.; Olivares, M.C.; Ballaz, A.; Madridano, O.; Soler, S.; Bertoletti, L.; Cañas, I.; Bura-Riviere, A.; Barrón, M.; Debourdeau, P.; Jaras, M.ªJ.; Gutiérrez, J.; Skride, A.; de Ancos, C.; García-Morillo, M.; Del Toro, J.; Lobo, J.L.; Gómez-Cuervo, C.; Sampériz, Á.; del Carmen Fernández-Criado, M.; Dentali, F.; Blanco-Molina, Á.; Moustafa, F.; Maida, R.; Aibar, J.; Ruiz-Ruiz, J.; Tolosa, C.; Porras, J.A.; Gavín-Sebastián, O.; Mastroiacovo, D.; Tapia, E.; García-Raso, A.; Blasco, L.H.; Pedrajas, J.M.; Peris, M.ªL.; Bui, H.M.; Romualdi, R.; Adarraga, M.ªD.; Lima, J.; López-Sáez, J.B.; Uresandi, F.; Marchena, P.J.; Pellejero, G.; Fernández-Capitán, C.; Benzidia, I.; Hij, A.; Garcia-Bragado, F.; Di Micco, P.; Martín, J.M.; Sinicalchi, C.; Tzoran, I.; Malý, R.; Celis, G.; Torres, M.I.; González-Martínez, J.; Rocci, A.; Sancho, T.; Pérez-Rus, G.; Villares, P.; Grau, E.; Pesavento, R.; Maestre, A.; Otero, R.; Vilaseca, A.; Bilora, F.; Valle, R.; Trujillo-Santos, J.; Alfonso, M.; Mumoli, N.; Rodríguez-Dávila, M.ªÁ.; Bosevski, M.; Lalueza, A.; Castro, J.; Bortoluzzi, C.; Hong, N.V.; Rubio, C.M.; Díaz-Peromingo, J.A.; Muñoz-Torrero, J.F.S.; del Pozo, G.; Caprini, J.A.; Bucherini, E.; Pace, F.; Hirmerova, J.; Prandoni, P.; López-Jiménez, L.; Font, C.; Barba, R.; Llamas, P.; Vanassche, T.; Jou, I.; Pham, K.Q.; Brandolin, B.; Visonà, A.; Farfán, A.I.; Bounameaux, H.; Rivas, A.; Díaz-Simón, R.; López-Miguel, P.; Salazar, V.; Gibietis, V.; Quintavalla, R.; Verhamme, P.; Ruiz-Sada, P.; Carrasco, C.; Barillari, G.; Nieto, J.A.; Jimenez, D.; Suriñach, J.M.; Gil-Díaz, A.; Monreal, M.; Lorente, M.A.; Reis, A.; Schellong, S.; Fidalgo, Á.; Braester, A.; Nieto, M.L.; Lorenzo, A.; Sharif-Kashani, B.; Tufano, A.; Camón, A.M.; Aibar, M.Á.; Falgá, C.; Ciammaichella, M.; Zalunardo, B.; Brenner, B.; del Carmen Gayol, M.; Morales, M.ªV.; Mahé, I.; Barrón-Andrés, B.; Arcelus, J.I.; Sahuquillo, J.C.; Farge-Bancel, D.; López-Núñez, J.J.; Parisi, R.; Fernández-Núñez, S.; Ruiz-Artacho, P.; García, M.A.; Núñez, M.J.; Loring, M.

doi:10.1038/s41598-019-55213-8

000097312 001__ 97312
000097312 005__ 20201221205838.0
000097312 0247_ $$2doi$$a10.1038/s41598-019-55213-8
000097312 0248_ $$2sideral$$a121367
000097312 037__ $$aART-2019-121367
000097312 041__ $$aeng
000097312 100__ $$aJara-Palomares, L.
000097312 245__ $$aComparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years
000097312 260__ $$c2019
000097312 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097312 5203_ $$aIn young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm, PREP, shock index and RIETE) in patients aged <50 years. We used the RIETE database, including PE patients from 2001 to 2017. The major outcome was 30-day all-cause mortality. Of 34, 651 patients with acute PE, 5, 822 (17%) were aged <50 years. Of these, 83 (1.4%) died during the first 30 days. Number of patients deemed low risk with tools was: PREP (95.9%), GPS (89.6%), PESI (87.2%), Shock index (70.9%), sPESI (59.4%), Prognostic algorithm (58%) and RIETE score (48.6%). The tools with a highest sensitivity were: Prognostic Algorithm (91.6%; 95% CI: 85.6–97.5), RIETE score (90.4%; 95%CI: 84.0–96.7) and sPESI (88%; 95% CI: 81–95). The RIETE, Prognostic Algorithm and sPESI scores obtained the highest overall sensitivity estimates for also predicting 7- and 90-day all-cause mortality, 30-day PE-related mortality, 30-day major bleeding and 30-day VTE recurrences. The proportion of low-risk patients who died within the first 30 days was lowest using the Prognostic Algorithm (0.2%), RIETE (0.3%) or sPESI (0.3%) scores. In PE patients less 50 years, 30-day mortality was low. Although sPESI, RIETE and Prognostic Algorithm scores were the most sensitive tools to identify patients at low risk to die, other tools should be evaluated in this population to obtain more efficient results.
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000097312 590__ $$a3.998$$b2019
000097312 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 71 = 0.239$$c2019$$dQ1$$eT1
000097312 592__ $$a1.341$$b2019
000097312 593__ $$aMultidisciplinary$$c2019$$dQ1
000097312 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097312 700__ $$aAlfonso, M.
000097312 700__ $$aMaestre, A.
000097312 700__ $$aJimenez, D.
000097312 700__ $$aGarcia-Bragado, F.
000097312 700__ $$aFont, C.
000097312 700__ $$aReyes, R.L.
000097312 700__ $$aBlasco, L.H.
000097312 700__ $$aVidal, G.
000097312 700__ $$aOtero, R.
000097312 700__ $$aMonreal, M.
000097312 700__ $$aAdarraga, M.ªD.
000097312 700__ $$0(orcid)0000-0002-1774-6488$$aAibar, M.Á.
000097312 700__ $$aAibar, J.
000097312 700__ $$aAmado, C.
000097312 700__ $$aArcelus, J.I.
000097312 700__ $$aBallaz, A.
000097312 700__ $$aBarba, R.
000097312 700__ $$aBarrón, M.
000097312 700__ $$aBarrón-Andrés, B.
000097312 700__ $$aBascuñana, J.
000097312 700__ $$aBlanco-Molina, Á.
000097312 700__ $$aCamón, A.M.
000097312 700__ $$aCañas, I.
000097312 700__ $$aCarrasco, C.
000097312 700__ $$aCastro, J.
000097312 700__ $$ade Ancos, C.
000097312 700__ $$aDel Toro, J.
000097312 700__ $$aDemelo, P.
000097312 700__ $$aDíaz-Peromingo, J.A.
000097312 700__ $$aDíaz-Simón, R.
000097312 700__ $$aFalgá, C.
000097312 700__ $$aFarfán, A.I.
000097312 700__ $$aFernández-Capitán, C.
000097312 700__ $$adel Carmen Fernández-Criado, M.
000097312 700__ $$aFernández-Núñez, S.
000097312 700__ $$aFidalgo, Á.
000097312 700__ $$aFont, L.
000097312 700__ $$aGarcía, M.A.
000097312 700__ $$aGarcía-Morillo, M.
000097312 700__ $$aGarcía-Raso, A.
000097312 700__ $$aGavín-Sebastián, O.
000097312 700__ $$adel Carmen Gayol, M.
000097312 700__ $$aGil-Díaz, A.
000097312 700__ $$aGómez, V.
000097312 700__ $$aGómez-Cuervo, C.
000097312 700__ $$aGonzález-Martínez, J.
000097312 700__ $$aGrau, E.
000097312 700__ $$aGutiérrez, J.
000097312 700__ $$aGutiérrez-González, S.
000097312 700__ $$aIglesias, M.
000097312 700__ $$aJaras, M.ªJ.
000097312 700__ $$aJou, I.
000097312 700__ $$aJoya, M.D.
000097312 700__ $$aLalueza, A.
000097312 700__ $$aLima, J.
000097312 700__ $$aLlamas, P.
000097312 700__ $$aLobo, J.L.
000097312 700__ $$aLópez-Jiménez, L.
000097312 700__ $$aLópez-Miguel, P.
000097312 700__ $$aLópez-Núñez, J.J.
000097312 700__ $$aLópez-Sáez, J.B.
000097312 700__ $$aLorente, M.A.
000097312 700__ $$aLorenzo, A.
000097312 700__ $$aLoring, M.
000097312 700__ $$aMadridano, O.
000097312 700__ $$aMarchena, P.J.
000097312 700__ $$aMartín, J.M.
000097312 700__ $$aMellado, M.
000097312 700__ $$aMorales, M.ªV.
000097312 700__ $$aNieto, M.L.
000097312 700__ $$aNieto, J.A.
000097312 700__ $$aNúñez, M.J.
000097312 700__ $$aOlivares, M.C.
000097312 700__ $$aPedrajas, J.M.
000097312 700__ $$aPellejero, G.
000097312 700__ $$aPérez-Rus, G.
000097312 700__ $$aPeris, M.ªL.
000097312 700__ $$aPorras, J.A.
000097312 700__ $$aRivas, A.
000097312 700__ $$aRodríguez-Dávila, M.ªÁ.
000097312 700__ $$aAdela Rodríguez-Hernández, A.
000097312 700__ $$aRubio, C.M.
000097312 700__ $$aRuiz-Artacho, P.
000097312 700__ $$aRuiz-Ruiz, J.
000097312 700__ $$aRuiz-Sada, P.
000097312 700__ $$aSahuquillo, J.C.
000097312 700__ $$aSalazar, V.
000097312 700__ $$aSampériz, Á.
000097312 700__ $$aMuñoz-Torrero, J.F.S.
000097312 700__ $$aSancho, T.
000097312 700__ $$aSoler, S.
000097312 700__ $$aSuriñach, J.M.
000097312 700__ $$aTapia, E.
000097312 700__ $$aTolosa, C.
000097312 700__ $$aTorres, M.I.
000097312 700__ $$aTrujillo-Santos, J.
000097312 700__ $$aUresandi, F.
000097312 700__ $$aValle, R.
000097312 700__ $$aVillares, P.
000097312 700__ $$aGutiérrez, P.
000097312 700__ $$aVázquez, F.J.
000097312 700__ $$aVilaseca, A.
000097312 700__ $$aVanassche, T.
000097312 700__ $$aVandenbriele, C.
000097312 700__ $$aVerhamme, P.
000097312 700__ $$aHirmerova, J.
000097312 700__ $$aMalý, R.
000097312 700__ $$aCelis, G.
000097312 700__ $$adel Pozo, G.
000097312 700__ $$aSalgado, E.
000097312 700__ $$aBenzidia, I.
000097312 700__ $$aBertoletti, L.
000097312 700__ $$aBura-Riviere, A.
000097312 700__ $$aDebourdeau, P.
000097312 700__ $$aFarge-Bancel, D.
000097312 700__ $$aHij, A.
000097312 700__ $$aMahé, I.
000097312 700__ $$aMoustafa, F.
000097312 700__ $$aSchellong, S.
000097312 700__ $$aBraester, A.
000097312 700__ $$aBrenner, B.
000097312 700__ $$aTzoran, I.
000097312 700__ $$aSharif-Kashani, B.
000097312 700__ $$aBarillari, G.
000097312 700__ $$aBilora, F.
000097312 700__ $$aBortoluzzi, C.
000097312 700__ $$aBrandolin, B.
000097312 700__ $$aBucherini, E.
000097312 700__ $$aCiammaichella, M.
000097312 700__ $$aDentali, F.
000097312 700__ $$aDi Micco, P.
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000097312 700__ $$aMastroiacovo, D.
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000097312 700__ $$aPace, F.
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000097312 700__ $$aPesavento, R.
000097312 700__ $$aPrandoni, P.
000097312 700__ $$aQuintavalla, R.
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000097312 700__ $$aZalunardo, B.
000097312 700__ $$aGibietis, V.
000097312 700__ $$aKigitovica, D.
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000097312 700__ $$aBosevski, M.
000097312 700__ $$aBounameaux, H.
000097312 700__ $$aMazzolai, L.
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000097312 773__ $$g9, 1 (2019), 20064 [10 pp]$$pSci. rep.$$tScientific Reports$$x2045-2322
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000097312 951__ $$a2020-12-21-19:25:32
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