000097322 001__ 97322
000097322 005__ 20210930085405.0
000097322 0247_ $$2doi$$a10.1016/j.bone.2020.115769
000097322 0248_ $$2sideral$$a121357
000097322 037__ $$aART-2020-121357
000097322 041__ $$aeng
000097322 100__ $$0(orcid)0000-0002-0255-6200$$aNasello, Gabriele$$uUniversidad de Zaragoza
000097322 245__ $$aMechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity
000097322 260__ $$c2020
000097322 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097322 5203_ $$aIt is well founded that the mechanical environment may regulate bone regeneration in orthopedic applications. The purpose of this study is to investigate the mechanical contributions of the scaffold and the host to bone regeneration, in terms of subject specificity, implantation site and sensitivity to the mechanical environment. Using a computational approach to model mechano-driven regeneration, bone ingrowth in porous titanium scaffolds was simulated in the distal femur and proximal tibia of three goats and compared to experimental results. The results showed that bone ingrowth shifted from a homogeneous distribution pattern, when scaffolds were in contact with trabecular bone (max local ingrowth 12.47%), to a localized bone ingrowth when scaffolds were implanted in a diaphyseal location (max local ingrowth 20.64%). The bone formation dynamics revealed an apposition rate of 0.37±0.28%/day in the first three weeks after implantation, followed by limited increase in bone ingrowth until the end of the experiment (12 weeks). According to in vivo data, we identified one animal whose sensitivity to mechanical stimulation was higher than the other two. Moreover, we found that the stimulus initiating bone formation was consistently higher in the femur than in the tibia for all the individuals. Overall, the dependence of the osteogenic response on the host biomechanics means that, from a mechanical perspective, the regenerative potential depends on both the scaffold and the host environment. Therefore, this work provides insights on how the mechanical conditions of both the recipient and the scaffold contribute to meet patient and location-specific characteristics.
000097322 536__ $$9info:eu-repo/grantAgreement/EC/H2020/722535/EU/Predictive models and simulations in bone regeneration: a multiscale patient-specific approach/CuraBone$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 722535-CuraBone
000097322 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000097322 590__ $$a4.398$$b2020
000097322 591__ $$aENDOCRINOLOGY & METABOLISM$$b54 / 145 = 0.372$$c2020$$dQ2$$eT2
000097322 592__ $$a1.346$$b2020
000097322 593__ $$aEndocrinology, Diabetes and Metabolism$$c2020$$dQ1
000097322 593__ $$aPhysiology$$c2020$$dQ1
000097322 593__ $$aHistology$$c2020$$dQ1
000097322 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097322 700__ $$aVautrin, Antoine
000097322 700__ $$aPitocchi, Jonathan
000097322 700__ $$aWesseling, Mariska
000097322 700__ $$aKuiper, Jan Herman
000097322 700__ $$0(orcid)0000-0002-2901-4188$$aPérez Ansón, María de los Ángeles$$uUniversidad de Zaragoza
000097322 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía Aznar, José Manuel$$uUniversidad de Zaragoza
000097322 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000097322 773__ $$g144 (2020), 115769 [13 pp.]$$pBone$$tBONE$$x8756-3282
000097322 8564_ $$s2018466$$uhttps://zaguan.unizar.es/record/97322/files/texto_completo.pdf$$yVersión publicada
000097322 8564_ $$s468998$$uhttps://zaguan.unizar.es/record/97322/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097322 909CO $$ooai:zaguan.unizar.es:97322$$particulos$$pdriver
000097322 951__ $$a2021-09-30-08:27:33
000097322 980__ $$aARTICLE