000097328 001__ 97328
000097328 005__ 20210104132018.0
000097328 0247_ $$2doi$$a10.1016/j.jmbbm.2019.103507
000097328 0248_ $$2sideral$$a115461
000097328 037__ $$aART-2019-115461
000097328 041__ $$aeng
000097328 100__ $$0(orcid)0000-0002-3613-4209$$aPuértolas, S.$$uUniversidad de Zaragoza
000097328 245__ $$aA comparative study of hyperelastic constitutive models for colonic tissue fitted to multiaxial experimental testing
000097328 260__ $$c2019
000097328 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097328 5203_ $$aFor colonic stents design, the interaction with colonic tissue is essential in order to characterize the appropriate radial stiffness which provides a minimum lumen for intestinal transit to be maintained. It is therefore important to develop suitable constitutive models allowing the mechanical behavior of the colon tissue to be characterized.
The present work investigates the biomechanical behavior of colonic tissue by means of biaxial tests carried out on different parts of the colonic tract taken from several porcine specimens. Samples from the colonic tract were quasi-statically tensioned using a load-controlled protocol with different tension ratios between the circumferential and the axial directions. Fitting techniques were then used to adjust specific hyperelastic models accounting for the multilayered conformation of the colonic wall and the fiber-reinforced configuration of the
corresponding tissues.
It was found that the porcine colon changed from a more isotropic to a more anisotropic tissue and became progressively more flexible and compliant in circumferential direction depending on the position along the duct as it approaches the rectum. The best predictive capability of mechanical behavior corresponds to the Four Fiber Family model showing mean values of coefficient of determination R2 ¼ 0:97, and a normalized root mean
square error of eNRMS ¼ 0:0814 for proximal spiral samples, and R2 ¼ 0:89 ; eNRMS ¼ 0:1600 and R2 ¼ 0:94 ; eNRMS ¼ 0:1227 for distal spiral and descending colon samples, respectively. The other analyzed models provide good results for proximal spiral colon specimens, which have a lower degree of anisotropy.
The analyzed models with the fitted elastic parameters can be used for more realistic and reliable FE simulations, providing the appropriate framework for the design of optimal devices for the treatment of colonic diseases.
000097328 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000097328 590__ $$a3.372$$b2019
000097328 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b19 / 38 = 0.5$$c2019$$dQ2$$eT2
000097328 591__ $$aENGINEERING, BIOMEDICAL$$b27 / 87 = 0.31$$c2019$$dQ2$$eT1
000097328 592__ $$a0.944$$b2019
000097328 593__ $$aMechanics of Materials$$c2019$$dQ1
000097328 593__ $$aBiomaterials$$c2019$$dQ2
000097328 593__ $$aBiomedical Engineering$$c2019$$dQ2
000097328 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000097328 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E.$$uUniversidad de Zaragoza
000097328 700__ $$0(orcid)0000-0002-8643-7558$$aHerrera, A.$$uUniversidad de Zaragoza
000097328 700__ $$0(orcid)0000-0003-0785-4132$$aIbarz, E.$$uUniversidad de Zaragoza
000097328 700__ $$0(orcid)0000-0001-7944-9625$$aGracia, L.$$uUniversidad de Zaragoza
000097328 7102_ $$11004$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Traumatología y Ortopedia
000097328 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000097328 773__ $$g102 (2019), 103507 1-15$$pJ. mech. behav. boomed. mater.$$tJournal of the Mechanical Behavior of Biomedical Materials$$x1751-6161
000097328 8564_ $$s8255410$$uhttps://zaguan.unizar.es/record/97328/files/texto_completo.pdf$$yPostprint
000097328 8564_ $$s238569$$uhttps://zaguan.unizar.es/record/97328/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000097328 909CO $$ooai:zaguan.unizar.es:97328$$particulos$$pdriver
000097328 951__ $$a2021-01-04-10:58:46
000097328 980__ $$aARTICLE