97350 20230519145447.0 doi 10.1109/TBME.2020.3043844 sideral 121417 ART-2021-121417 eng Bukhari, Syed Hassaan Ahmed Universidad de Zaragoza (orcid)0000-0001-5976-0483 Characterization of t wave amplitude, duration and morphology changes during hemodialysis: Relationship with serum electrolyte levels and heart rate 2021 Access copy available to the general public Unrestricted Objective: Chronic kidney disease affects more than 10% of the world population. Changes in serum ion concentrations increase the risk for ventricular arrhythmias and sudden cardiac death, particularly in end stage renal disease (ESRD) patients. We characterized how T wave amplitude, duration and morphology descriptors change with variations in serum levels of potassium and calcium and in heart rate, both in ESRD patients and in simulated ventricular fibers. Methods: Electrocardiogram (ECG) recordings from twenty ESRD patients undergoing hemodialysis (HD) and pseudo-ECGs (pECGs) calculated from twenty-two simulated ventricular fibers at varying transmural heterogeneity levels were processed to quantify T wave width (Tw), T wave slope-to-amplitude ratio (TS/A) and four indices of T wave morphological variability based on time warping (dw, dNLw, da and dNLa). Serum potassium and calcium levels and heart rate were measured along HD. Results: dNL with serum potassium, dw with calcium and da with heart rate, after correction for covariates. Median values of partial correlation coefficients were 0.75,−0.74 and −0.90, respectively. For all analyzed T wave descriptors, high inter-patient variability was observed in the pattern of such relationships. This variability, accentuated during the first HD time points, was reproduced in the simulations and shown to be influenced by differences in transmural heterogeneity. Conclusion: Changes in serum potassium and calcium levels and in heart rate strongly affect T wave descriptors, particularly those quantifying morphological variability. Significance: ECG markers have the potential to be used for monitoring serum ion concentrations in ESRD patients. info:eu-repo/grantAgreement/ES/DGA-FSE/LMP124-18 info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE info:eu-repo/grantAgreement/EC/H2020/764738/EU/Personalised In-Silico Cardiology/PIC This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 764738-PIC info:eu-repo/grantAgreement/EC/H2020/786833/EU/GENetics and the Electrocardiogram for predicting Scd rISk/GENESIS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 786833-GENESIS info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00 info:eu-repo/grantAgreement/ES/MICIU/PID2019-105674RB-I00 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.756 2021 ENGINEERING, BIOMEDICAL 37 / 98 = 0.378 2021 Q2 T2 1.298 2021 Biomedical Engineering 2021 Q1 9.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Palmieri, Flavio Ramírez, Julia (orcid)0000-0003-4130-5866 Laguna, Pablo Universidad de Zaragoza (orcid)0000-0003-3434-9254 Ruiz, José Esteban Universidad de Zaragoza (orcid)0000-0002-4351-8518 Ferreira, Dina Potse, Mark Sánchez, Carlos Universidad de Zaragoza (orcid)0000-0003-4273-5403 Pueyo, Esther Universidad de Zaragoza (orcid)0000-0002-1960-407X 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 68, 8 (2021), 2467-2478 IEEE trans. biomed. eng. IEEE Transactions on Biomedical Engineering 0018-9294 2459921 http://zaguan.unizar.es/record/97350/files/texto_completo.pdf Postprint 25981 http://zaguan.unizar.es/record/97350/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:97350 articulos driver 2023-05-18-14:39:50 ARTICLE