97382 20210902121933.0 doi 10.3390/polym12122872 sideral 121767 ART-2020-121767 eng Concellón, A. (orcid)0000-0002-8932-9085 Micellar nanocarriers from dendritic macromolecules containing fluorescent coumarin moieties 2020 Access copy available to the general public Unrestricted The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications. info:eu-repo/grantAgreement/ES/DGA-FEDER/E47-17R info:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-097583-B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.329 2020 POLYMER SCIENCE 18 / 88 = 0.205 2020 Q1 T1 0.77 2020 Polymers and Plastics 2020 Q1 Chemistry (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Anselmo, M.S. Universidad de Zaragoza (orcid)0000-0003-0063-9456 Hernández-Ainsa, S. Universidad de Zaragoza (orcid)0000-0003-3109-4284 Romero, P. Universidad de Zaragoza (orcid)0000-0003-1378-0571 Marcos, M. (orcid)0000-0001-7056-3181 Serrano, J.L. Universidad de Zaragoza (orcid)0000-0001-9866-6633 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 12, 12 (2020), 2872 [1-11] Polymers (Basel) POLYMERS 2073-4360 1484816 http://zaguan.unizar.es/record/97382/files/texto_completo.pdf Versión publicada 497804 http://zaguan.unizar.es/record/97382/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:97382 articulos driver 2021-09-02-10:56:24 ARTICLE