000097399 001__ 97399
000097399 005__ 20220223111655.0
000097399 0247_ $$2doi$$a10.1038/s41598-020-77249-x
000097399 0248_ $$2sideral$$a121784
000097399 037__ $$aART-2020-121784
000097399 041__ $$aeng
000097399 100__ $$0(orcid)0000-0003-2266-8602$$aIglesias, M.J.$$uUniversidad de Zaragoza
000097399 245__ $$aThe value of the continuous genotyping of multi-drug resistant tuberculosis over 20 years in Spain
000097399 260__ $$c2020
000097399 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097399 5203_ $$aMolecular epidemiology of circulating clinical isolates is crucial to improve prevention strategies. The Spanish Working Group on multidrug resistant tuberculosis (MDR-TB) is a network that monitors the MDR-TB isolates in Spain since 1998. The aim of this study was to present the study of the MDR-TB and extensively drug-resistant tuberculosis (XDR-TB) patterns in Spain using the different recommended genotyping methods over time by a national coordinated system. Based on the proposed genotyping methods in the European Union until 2018, the preservation of one method, MIRU-VNTR, applied to selected clustered strains permitted to maintain our study open for 20 years. The distribution of demographic, clinical and epidemiological characteristics of clustered and non-clustered cases of MDR/XDR tuberculosis with proportion differences as assessed by Pearson’s chi-squared or Fisher’s exact test was compared. The differences in the quantitative variables using the Student's-t test and the Mann–Whitney U test were evaluated. The results obtained showed a total of 48.4% of the cases grouped in 77 clusters. Younger age groups, having a known TB case contact (10.2% vs 4.7%) and XDR-TB (16.5% vs 1.8%) were significantly associated with clustering. The largest cluster corresponded to a Mycobacterium bovis strain mainly spread during the nineties. A total of 68.4% of the clusters detected were distributed among the different Spanish regions and six clusters involving 104 cases were grouped in 17 and 18 years. Comparison of the genotypes obtained with those European genotypes included in The European Surveillance System (TESSy) showed that 87 cases had become part of 20 European clusters. The continuity of MDR strain genotyping in time has offered a widespread picture of the situation that allows better management of this public health problem. It also shows the advantage of maintaining one genotyping method over time, which allowed the comparison between ancient, present and future samples.
000097399 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/Building Europe from Aragon$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS15-0317$$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-0336
000097399 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097399 590__ $$a4.379$$b2020
000097399 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 73 = 0.233$$c2020$$dQ1$$eT1
000097399 592__ $$a1.24$$b2020
000097399 593__ $$aMultidisciplinary$$c2020$$dQ1
000097399 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097399 700__ $$aIbarz, D.
000097399 700__ $$0(orcid)0000-0002-3312-7759$$aCebollada, A.
000097399 700__ $$aComín, J.
000097399 700__ $$aJiménez, M.S.
000097399 700__ $$aVázquez, M.C.
000097399 700__ $$0(orcid)0000-0002-3011-2519$$aSamper, S.$$uUniversidad de Zaragoza
000097399 700__ $$aCabezas, T.
000097399 700__ $$aReyes, A.
000097399 700__ $$aRuiz, I.
000097399 700__ $$aGarcía, P.
000097399 700__ $$aLópez, M.D.
000097399 700__ $$aCardeñoso, L.
000097399 700__ $$ade la Calle, I.J.
000097399 700__ $$aRuiz, P.
000097399 700__ $$aAlados, J.C.
000097399 700__ $$aRomán, J.
000097399 700__ $$aVilla-Real, R.
000097399 700__ $$aSaavedra, J.
000097399 700__ $$aAmores, C.
000097399 700__ $$aBermúdez, P.
000097399 700__ $$aSánchez, M.A.
000097399 700__ $$aMontiel, N.
000097399 700__ $$aBernal, S.
000097399 700__ $$aLepe, J.A.
000097399 700__ $$aBatista, N.
000097399 700__ $$aRoldán, E.
000097399 700__ $$aTorres, L.
000097399 700__ $$aNavarro, C.
000097399 700__ $$aChocarro, P.
000097399 700__ $$aAldea, M.J.
000097399 700__ $$aViñuelas, J.
000097399 700__ $$aVitoria, M.A.
000097399 700__ $$aPalacios, J.J.
000097399 700__ $$aVillar, H.
000097399 700__ $$aPrendes, P.
000097399 700__ $$aBlanco, M.
000097399 700__ $$aVázquez, F.
000097399 700__ $$aTelenti, M.
000097399 700__ $$aSánchez, I.
000097399 700__ $$aCarbo, L.
000097399 700__ $$aEscobar, S.
000097399 700__ $$aRamírez, A.
000097399 700__ $$aGallegos, C.
000097399 700__ $$aPérez, M.C.
000097399 700__ $$aLecuona, M.
000097399 700__ $$aDíez, O.
000097399 700__ $$aCopado, R.
000097399 700__ $$aCampos, I.
000097399 700__ $$aCañas, F.
000097399 700__ $$aSalas, C.
000097399 700__ $$aFernández, C.
000097399 700__ $$aRoíz, M.P.
000097399 700__ $$aBarba, I.
000097399 700__ $$aManrique, E.
000097399 700__ $$aCarranza, R.
000097399 700__ $$aMaroto, A.S.
000097399 700__ $$aGonzález, A.
000097399 700__ $$aRodríguez, E.
000097399 700__ $$aMartino, V.
000097399 700__ $$aSánchez, C.
000097399 700__ $$aMartínez, C.
000097399 700__ $$aRobles, P.
000097399 700__ $$aSimarro, E.
000097399 700__ $$aRomero, C.
000097399 700__ $$aLópez, R.
000097399 700__ $$aBlanco, M.D.
000097399 700__ $$aNebreda, T.
000097399 700__ $$aRodríguez, J.
000097399 700__ $$aFernández, J.M.
000097399 700__ $$aÁlvarez, E.
000097399 700__ $$aJaime, M.L.
000097399 700__ $$aTejero, M.D.
000097399 700__ $$aAlberte, A.
000097399 700__ $$aOteda, E.
000097399 700__ $$aMegías, G.
000097399 700__ $$aLabayru, C.
000097399 700__ $$aIbáñez, R.
000097399 700__ $$aCampos, A.
000097399 700__ $$aCarrero, P.
000097399 700__ $$aVilló, J.M.
000097399 700__ $$aSans, T.
000097399 700__ $$aPujol, I.
000097399 700__ $$aClivillé, X.
000097399 700__ $$aCastellví, J.B.
000097399 700__ $$ade Batlle, J.
000097399 700__ $$aMariscal, D.
000097399 700__ $$aPrat, C.
000097399 700__ $$aGarcía, M.
000097399 700__ $$aAlcalde, F.
000097399 700__ $$aGallén, C.
000097399 700__ $$aSauca, G.
000097399 700__ $$aCuchi, E.
000097399 700__ $$aAlonso, C.
000097399 700__ $$aCorcoy, F.
000097399 700__ $$aSchmidt, G.
000097399 700__ $$aTortola, M.T.
000097399 700__ $$aGarduño, E.
000097399 700__ $$aMoreno, J.J.
000097399 700__ $$aHernández, P.
000097399 700__ $$aMontes, I.
000097399 700__ $$aRoman, J.
000097399 700__ $$aAlonso, P.
000097399 700__ $$aRodríguez, A.
000097399 700__ $$aBarbeyto, L.
000097399 700__ $$aFernández, B.
000097399 700__ $$aDomínguez, D.
000097399 700__ $$aVillanueva, R.
000097399 700__ $$aIglesias, I.
000097399 700__ $$aVasallo, F.J.
000097399 700__ $$aSevillano, J.
000097399 700__ $$aPascual, A.
000097399 700__ $$aGarcía, M.
000097399 700__ $$aPérez del Molino, M.L.
000097399 700__ $$aMartino, V.
000097399 700__ $$aUgalde, E.
000097399 700__ $$aDopereiro, R.
000097399 700__ $$aCuadros, J.A.
000097399 700__ $$aPelayo, I.
000097399 700__ $$aCacho, J.
000097399 700__ $$aCogollos, R.
000097399 700__ $$aPáez, M.
000097399 700__ $$aPrieto, S.
000097399 700__ $$aFernández, R.
000097399 700__ $$aLópez, P.
000097399 700__ $$aDomingo, D.
000097399 700__ $$aMillán, R.
000097399 700__ $$aBonilla, I.
000097399 700__ $$aMerino, P.
000097399 700__ $$aToro, C.
000097399 700__ $$aRuiz, M.J.
000097399 700__ $$aMenéndez, M.
000097399 700__ $$aRomero, P.
000097399 700__ $$aTato, M.
000097399 700__ $$aSimón, M.
000097399 700__ $$aUrmeneta, A.
000097399 700__ $$aDelgado, A.
000097399 700__ $$aGarcía, L.
000097399 700__ $$aCobos, J.
000097399 700__ $$aMerino, J.
000097399 700__ $$aAznar, E.
000097399 700__ $$aPiqueras, J.
000097399 700__ $$aNavarro, M.D.
000097399 700__ $$aArtero, J.M.
000097399 700__ $$aNavascués, A.
000097399 700__ $$aGil, A.
000097399 700__ $$aLeiva, J.
000097399 700__ $$aElorduy, L.
000097399 700__ $$aUrra, E.
000097399 700__ $$aIdígoras, P.
000097399 700__ $$aPérez-Trallero, E.
000097399 700__ $$aCanut, A.
000097399 700__ $$aBarrios, J.L.
000097399 700__ $$aMichans, L.
000097399 700__ $$aAyarza, R.
000097399 700__ $$aGarcía, F.
000097399 700__ $$aUnzaga, M.J.
000097399 700__ $$aNavarro, M.
000097399 700__ $$aGonzalo, N.
000097399 700__ $$aMartín, C.
000097399 700__ $$aMartínez, C.
000097399 700__ $$aGimeno, A.
000097399 700__ $$aElia, M.
000097399 700__ $$aLópez, P.
000097399 700__ $$aSabater, S.
000097399 700__ $$aRodríguez, J.C.
000097399 700__ $$aSantos, M.
000097399 700__ $$aBosque, M.
000097399 700__ $$aLópez, J.
000097399 700__ $$aTabernero, E.
000097399 700__ $$aGalán, M.I.
000097399 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000097399 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000097399 773__ $$g10, 1 (2020), 20433 [12 pp]$$pSci. rep.$$tScientific Reports$$x2045-2322
000097399 8564_ $$s708014$$uhttps://zaguan.unizar.es/record/97399/files/texto_completo.pdf$$yVersión publicada
000097399 8564_ $$s308437$$uhttps://zaguan.unizar.es/record/97399/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097399 909CO $$ooai:zaguan.unizar.es:97399$$particulos$$pdriver
000097399 951__ $$a2022-02-23-11:13:13
000097399 980__ $$aARTICLE