000097405 001__ 97405
000097405 005__ 20240104111817.0
000097405 0247_ $$2doi$$a10.3390/ijms21249582
000097405 0248_ $$2sideral$$a121474
000097405 037__ $$aART-2020-121474
000097405 041__ $$aeng
000097405 100__ $$0(orcid)0000-0003-2436-7205$$aMoreno-García, L.$$uUniversidad de Zaragoza
000097405 245__ $$aCompeting endogenous rna networks as biomarkers in neurodegenerative diseases
000097405 260__ $$c2020
000097405 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097405 5203_ $$aProtein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcriptome and are particularly abundant in the central nervous system, where they have been proposed to be involved in the onset and development of NDDs. Interestingly, some ncRNAs (such as lncRNAs, circRNAs and pseudogenes) share a common functionality in their ability to regulate gene expression by modulating miRNAs in a phenomenon known as the competing endogenous RNA mechanism. Moreover, ncRNAs are found in body fluids where their presence and concentration could serve as potential non-invasive biomarkers of NDDs. In this review, we summarize the ceRNA networks described in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis and spinocerebellar ataxia type 7, and discuss their potential as biomarkers of these NDDs. Although numerous studies have been carried out, further research is needed to validate these complex interactions between RNAs and the alterations in RNA editing that could provide specific ceRNET profiles for neurodegenerative disorders, paving the way to a better understanding of these diseases.
000097405 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europa$$9info:eu-repo/grantAgreement/ES/DGA-FSE/Departamento de Industria e Innovación$$9info:eu-repo/grantAgreement/ES/DGA/Grupos Consolidados$$9info:eu-repo/grantAgreement/ES/FIS-FEDER/PI17-00949$$9info:eu-repo/grantAgreement/ES/MCIU/Gobierno de España
000097405 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097405 590__ $$a5.923$$b2020
000097405 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b67 / 296 = 0.226$$c2020$$dQ1$$eT1
000097405 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b49 / 178 = 0.275$$c2020$$dQ2$$eT1
000097405 592__ $$a1.455$$b2020
000097405 593__ $$aCatalysis$$c2020$$dQ1
000097405 593__ $$aComputer Science Applications$$c2020$$dQ1
000097405 593__ $$aInorganic Chemistry$$c2020$$dQ1
000097405 593__ $$aSpectroscopy$$c2020$$dQ1
000097405 593__ $$aMolecular Biology$$c2020$$dQ1
000097405 593__ $$aOrganic Chemistry$$c2020$$dQ1
000097405 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1
000097405 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000097405 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000097405 700__ $$0(orcid)0000-0001-9802-8199$$aLópez-Royo, T.$$uUniversidad de Zaragoza
000097405 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, A.C.$$uUniversidad de Zaragoza
000097405 700__ $$0(orcid)0000-0002-7243-1737$$aToivonen, J.M.$$uUniversidad de Zaragoza
000097405 700__ $$0(orcid)0000-0002-7955-7164$$ade la Torre, M.$$uUniversidad de Zaragoza
000097405 700__ $$0(orcid)0000-0002-7277-4318$$aMoreno-Martínez, L.
000097405 700__ $$aMolina, N.
000097405 700__ $$0(orcid)0000-0001-5612-0253$$aAparicio, P.
000097405 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, P.$$uUniversidad de Zaragoza
000097405 700__ $$0(orcid)0000-0002-7477-8742$$aManzano, R.$$uUniversidad de Zaragoza
000097405 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, R.$$uUniversidad de Zaragoza
000097405 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000097405 773__ $$g21, 24 (2020), 9582 [1-42 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000097405 8564_ $$s710868$$uhttps://zaguan.unizar.es/record/97405/files/texto_completo.pdf$$yVersión publicada
000097405 8564_ $$s462722$$uhttps://zaguan.unizar.es/record/97405/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000097405 951__ $$a2024-01-04-11:05:28
000097405 980__ $$aARTICLE