000097432 001__ 97432
000097432 005__ 20210902121839.0
000097432 0247_ $$2doi$$a10.1371/journal.pone.0243236
000097432 0248_ $$2sideral$$a121730
000097432 037__ $$aART-2020-121730
000097432 041__ $$aeng
000097432 100__ $$aCordon, B.
000097432 245__ $$aAngiography with optical coherence tomography as a biomarker in multiple sclerosis
000097432 260__ $$c2020
000097432 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097432 5203_ $$aPurpose
To investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls.
Methods
A total of 92 eyes from 92 patients with relapsing-remitting MS and 149 control eyes were included in this prospective observational study. OCT-A imaging was performed using Triton Swept-Source OCT (Topcon Corporation, Japan). The vessel density (VD) percentage in the superficial retinal plexus and optic disc area (6 x 6 mm grid) was measured and compared between groups.
Results
MS patients showed a significant decrease VD in the superior (p = 0.005), nasal (p = 0.029) and inferior (p = 0.040) parafoveal retina compared with healthy subjects. Patients with disease durations of more than 5 years presented lower VD in the superior (p = 0.002), nasal (p = 0.017) and inferior (p = 0.022) parafoveal areas compared with healthy subjects. Patients with past optic neuritis episodes did not show retinal microvasculature alterations, but patients with an EDSS score of less than 3 showed a significant decrease in nasal (p = 0.024) and superior (p = 0.006) perifoveal VD when compared with healthy subjects.
Conclusions
MS produces a decrease in retinal vascularization density in the superficial plexus of the parafoveal retina. Alterations in retinal vascularization observed in MS patients are independent of the presence of optic nerve inflammation. OCT-A has the ability to detect subclinical vascular changes and is a potential biomarker for diagnosing the presence and progression of MS.
000097432 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097432 590__ $$a3.24$$b2020
000097432 591__ $$aMULTIDISCIPLINARY SCIENCES$$b26 / 73 = 0.356$$c2020$$dQ2$$eT2
000097432 592__ $$a0.99$$b2020
000097432 593__ $$aMultidisciplinary$$c2020$$dQ1
000097432 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097432 700__ $$aVilades, E.
000097432 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna, E.$$uUniversidad de Zaragoza
000097432 700__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.$$uUniversidad de Zaragoza
000097432 700__ $$aPerez-Velilla, J.
000097432 700__ $$aSebastian, B.
000097432 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000097432 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000097432 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000097432 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000097432 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000097432 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000097432 773__ $$g15, 12 December (2020), e0243236[15 pp]$$pPLoS One$$tPloS one$$x1932-6203
000097432 8564_ $$s769918$$uhttps://zaguan.unizar.es/record/97432/files/texto_completo.pdf$$yVersión publicada
000097432 8564_ $$s410068$$uhttps://zaguan.unizar.es/record/97432/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097432 909CO $$ooai:zaguan.unizar.es:97432$$particulos$$pdriver
000097432 951__ $$a2021-09-02-10:22:24
000097432 980__ $$aARTICLE