000097434 001__ 97434
000097434 005__ 20230622083318.0
000097434 0247_ $$2doi$$a10.3390/microorganisms8121966
000097434 0248_ $$2sideral$$a121732
000097434 037__ $$aART-2020-121732
000097434 041__ $$aeng
000097434 100__ $$0(orcid)0000-0001-5750-3643$$aPeris, M.P.$$uUniversidad de Zaragoza
000097434 245__ $$aNeutrophil gelatinase-associated lipocalin (NGAL) is related with the proteinuria degree and the microscopic kidney findings in leishmania-infected dogs
000097434 260__ $$c2020
000097434 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097434 5203_ $$aEarly diagnosis of renal damage in Leishmania infected dogs may allow appropriate treatments and prevent some deaths. This study investigates neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of kidney disease in dogs experimentally infected with Leishmania infantum. Serum, urine, and kidney samples were collected from 30 infected beagle dogs and six uninfected control dogs. Based on proteinuria and azotemia values, dogs were initially classified. NGAL was measured in urine and serum samples. Then, the urinary NGAL to creatinine ratio (uNGAL/C) was calculated. Kidney samples were taken for histopathological studies, and the dogs were classified according to the severity of glomerular and tubulointerstitial lesions. In Leishmania-infected dogs, the uNGAL/C was significantly higher in proteinuric non-azotemic dogs compared with non-proteinuric non-azotemic dogs (p = 0.038). Serum NGAL (sNGAL) concentration did not differ between groups. Microscopic studies revealed several degrees of glomerulonephritis and slight focal lymphoplasmacytic interstitial nephritis in 89% and 55% of infected dogs, respectively. Urinary protein to creatinine ratio (UPC) and uNGAL/C were significantly higher in dogs with affected glomeruli compared to infected dogs without renal lesions (p = 0.045 and p = 0.043, respectively). The results show that uNGAL/C correlates with proteinuria and the presence of moderate glomerular lesions in non-azotemic dogs experimentally infected with L. infantum.
000097434 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097434 590__ $$a4.128$$b2020
000097434 591__ $$aMICROBIOLOGY$$b52 / 136 = 0.382$$c2020$$dQ2$$eT2
000097434 592__ $$a0.857$$b2020
000097434 593__ $$aMicrobiology$$c2020$$dQ2
000097434 593__ $$aVirology$$c2020$$dQ2
000097434 593__ $$aMicrobiology (medical)$$c2020$$dQ2
000097434 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097434 700__ $$0(orcid)0000-0001-9778-6545$$aMorales, M.$$uUniversidad de Zaragoza
000097434 700__ $$aAres-Gómez, S.
000097434 700__ $$0(orcid)0000-0002-8282-5975$$aEsteban-Gil, A.
000097434 700__ $$0(orcid)0000-0001-5504-1393$$aGómez-Ochoa, P.$$uUniversidad de Zaragoza
000097434 700__ $$0(orcid)0000-0002-5927-073X$$aGascón, M.$$uUniversidad de Zaragoza
000097434 700__ $$0(orcid)0000-0001-6629-6842$$aMoreno, B.$$uUniversidad de Zaragoza
000097434 700__ $$0(orcid)0000-0002-2048-4749$$aCastillo, J.A.$$uUniversidad de Zaragoza
000097434 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000097434 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000097434 773__ $$g8, 12 (2020), 1966 [1-12]$$pMicroorganisms$$tMicroorganisms$$x2076-2607
000097434 8564_ $$s573360$$uhttps://zaguan.unizar.es/record/97434/files/texto_completo.pdf$$yVersión publicada
000097434 8564_ $$s500042$$uhttps://zaguan.unizar.es/record/97434/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097434 909CO $$ooai:zaguan.unizar.es:97434$$particulos$$pdriver
000097434 951__ $$a2023-06-21-15:02:48
000097434 980__ $$aARTICLE