000097437 001__ 97437 000097437 005__ 20210902121842.0 000097437 0247_ $$2doi$$a10.3390/molecules25235663 000097437 0248_ $$2sideral$$a121735 000097437 037__ $$aART-2020-121735 000097437 041__ $$aeng 000097437 100__ $$aRajkowska, K. 000097437 245__ $$aAntifungal Activity of Polyoxometalate-Ionic Liquids on Historical Brick 000097437 260__ $$c2020 000097437 5060_ $$aAccess copy available to the general public$$fUnrestricted 000097437 5203_ $$aMoulds inhabiting mineral-based materials may cause their biodeterioration, contributing to inestimable losses, especially in the case of cultural heritage objects and architectures. Fungi in mouldy buildings may also pose a threat to human health and constitute the main etiological factor in building related illnesses. In this context, research into novel compounds with antifungal activity is of high importance. The aim of this study was to evaluate the antifungal activity of polyoxometalate-ionic liquids (POM-ILs) and their use in the eradication of moulds from historical brick. In the disc diffusion assay, all the tested POM-ILs inhibited growth of a mixed culture of moulds including Engyodontium album, Cladosporium cladosporioides, Alternaria alternata and Aspergillus fumigatus. These were isolated from the surfaces of historical brick barracks at the Auschwitz II-Birkenau State Museum in Oswiecim, Poland. POM-IL coatings on historical brick samples, under model conditions, showed that two compounds demonstrated very high antifungal activity, completely limiting mould growth and development. The antifungal activity of the POM-ILs appeared to stem from their toxic effects on conidia, as evidenced by environmental scanning transmission electron microscopy observations. The results herein indicated that POM-ILs are promising disinfectant materials for use not only on historical objects, but probably also on other mineral-based materials. 000097437 536__ $$9info:eu-repo/grantAgreement/EC/H2020/845427/EU/Peptide-functionalized POMs as biofilm disruption agents: searching for synergy in bactericidal materials/PePiPOM$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 845427-PePiPOM$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-109333RB-I00 000097437 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000097437 590__ $$a4.411$$b2020 000097437 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b63 / 178 = 0.354$$c2020$$dQ2$$eT2 000097437 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b116 / 297 = 0.391$$c2020$$dQ2$$eT2 000097437 592__ $$a0.782$$b2020 000097437 593__ $$aAnalytical Chemistry$$c2020$$dQ1 000097437 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1 000097437 593__ $$aDrug Discovery$$c2020$$dQ1 000097437 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1 000097437 593__ $$aMolecular Medicine$$c2020$$dQ1 000097437 593__ $$aOrganic Chemistry$$c2020$$dQ1 000097437 593__ $$aPharmaceutical Science$$c2020$$dQ1 000097437 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000097437 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000097437 700__ $$aKoziróg, A. 000097437 700__ $$aOtlewska, A. 000097437 700__ $$aPiotrowska, M. 000097437 700__ $$0(orcid)0000-0002-3830-7847$$aAtrián-Blasco, E. 000097437 700__ $$0(orcid)0000-0002-8263-0473$$aFranco-Castillo, I. 000097437 700__ $$0(orcid)0000-0003-4848-414X$$aMitchell, S.G.$$uUniversidad de Zaragoza 000097437 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000097437 773__ $$g25, 23 (2020), 5663 [10 pp]$$pMolecules$$tMolecules$$x1420-3049 000097437 8564_ $$s559231$$uhttps://zaguan.unizar.es/record/97437/files/texto_completo.pdf$$yVersión publicada 000097437 8564_ $$s514761$$uhttps://zaguan.unizar.es/record/97437/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000097437 909CO $$ooai:zaguan.unizar.es:97437$$particulos$$pdriver 000097437 951__ $$a2021-09-02-10:24:33 000097437 980__ $$aARTICLE