97451 20230421130008.0 doi 10.1186/s13195-020-00734-y sideral 121698 ART-2020-121698 eng Röhr, S. Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study 2020 Access copy available to the general public Unrestricted Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods: We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results: The sample comprised 39, 387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3–24.4%) and IRT (25.6%, 95%CI = 25.1–26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1–7.0%, to 52.7%, 95%CI = 47.4–58.0%; IRT: 7.8%, 95%CI = 6.8–8.9%, to 52.7%, 95%CI = 47.4–58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions: SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field. info:eu-repo/grantAgreement/ES/DGA-FEDER/Group 19 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.982 2020 NEUROSCIENCES 38 / 273 = 0.139 2020 Q1 T1 CLINICAL NEUROLOGY 21 / 208 = 0.101 2020 Q1 T1 2.802 2020 Cognitive Neuroscience 2020 Q1 Neurology (clinical) 2020 Q1 Neurology 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pabst, A. Riedel-Heller, S.G. Jessen, F. Turana, Y. Handajani, Y.S. Brayne, C. Matthews, F.E. Stephan, B.C.M. Lipton, R.B. Katz, M.J. Wang, C. Guerchet, M. Preux, P.M. Mbelesso, P. Ritchie, K. Ancelin, M.L. Carrière, I. Guaita, A. Davin, A. Vaccaro, R. Kim, K.W. Han, J.W. Suh, S.W. Shahar, S. Din, N.C. Vanoh, D. van Boxtel, M. Köhler, S. Ganguli, M. Jacobsen, E.P. Snitz, B.E. Anstey, K.J. Cherbuin, N. Kumagai, S. Chen, S. Narazaki, K. Ng, T.P. Gao, Q. Gwee, X. Brodaty, H. Kochan, N.A. Trollor, J. Lobo, A. Universidad de Zaragoza (orcid)0000-0002-9098-655X López-Antón, R. Universidad de Zaragoza (orcid)0000-0002-3360-7015 Santabárbara, J. Universidad de Zaragoza (orcid)0000-0002-7297-6104 Crawford, J.D. Lipnicki, D.M. Sachdev, P.S. 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 12, 1 (2020), 167 [14 pp] Alzheimer's research & therapy Alzheimer's research & therapy 1758-9193 761131 http://zaguan.unizar.es/record/97451/files/texto_completo.pdf Versión publicada 47195 http://zaguan.unizar.es/record/97451/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:97451 articulos driver 2023-04-21-12:41:12 ARTICLE