000097463 001__ 97463
000097463 005__ 20220621094623.0
000097463 0247_ $$2doi$$a10.1177/0004563220980495
000097463 0248_ $$2sideral$$a121660
000097463 037__ $$aART-2020-121660
000097463 041__ $$aeng
000097463 100__ $$aFabre, M.
000097463 245__ $$aSARS-CoV-2 immunochromatographic IgM/IgG rapid test in pregnancy: A false friend?
000097463 260__ $$c2020
000097463 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097463 5203_ $$aBackground: An increasing body of evidence has revealed that SARS-CoV-2 infection in pregnant women could increase the risk of adverse maternal and fetal outcomes. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted. Therefore, rapid antibody tests have been suggested as an efficient screening tool during pregnancy.
Cases: We analysed the clinical performance during pregnancy of a rapid, lateral-flow immunochromatographic assay for qualitative detection of SARS-CoV-2 IgG/IgM antibodies. We performed a universal screening including 169 patients during their last trimester of pregnancy. We present a series of 14 patients with positive SARS-CoV-2 immunochromatographic assay rapid test result. Immunochromatographic assay results were always confirmed by chemiluminescent microparticle immunoassays for quantitative detection of SARS-CoV-2 IgG and IgM+IgA antibodies as the gold standard. We observed a positive predictive value of 50% and a false positive rate of 50% in pregnant women, involving a significantly lower diagnostic performance than reported in non-pregnant patients.
Discussion: Our data suggest that although immunochromatographic assay rapid tests may be a fast and profitable screening tool for SARS-CoV-2 infection, they may have a high false positive rate and low positive predictive value in pregnant women. Therefore, immunochromatographic assay for qualitative detection of SARS-CoV-2 IgG/IgM antibodies must be verified by other test in pregnant patients.
000097463 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CM18-00202$$9info:eu-repo/grantAgreement/ES/ISCIII/JR19-00006
000097463 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000097463 590__ $$a2.057$$b2020
000097463 591__ $$aMEDICAL LABORATORY TECHNOLOGY$$b20 / 29 = 0.69$$c2020$$dQ3$$eT3
000097463 592__ $$a0.6$$b2020
000097463 593__ $$aMedicine (miscellaneous)$$c2020$$dQ2
000097463 593__ $$aClinical Biochemistry$$c2020$$dQ2
000097463 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097463 700__ $$aRuiz-Martinez, S.
000097463 700__ $$aMonserrat Cantera, M.E.
000097463 700__ $$aCortizo Garrido, A.
000097463 700__ $$aBeunza Fabra, Z.
000097463 700__ $$aPeran, M.
000097463 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, R.$$uUniversidad de Zaragoza
000097463 700__ $$0(orcid)0000-0002-2218-5240$$aMateo, P.$$uUniversidad de Zaragoza
000097463 700__ $$0(orcid)0000-0001-6795-0367$$aPaules, C.$$uUniversidad de Zaragoza
000097463 700__ $$0(orcid)0000-0002-8476-9161$$aOros, D.$$uUniversidad de Zaragoza
000097463 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000097463 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000097463 773__ $$g58, 2 (2020), 149-152$$pAnn. clin. biochem.$$tANNALS OF CLINICAL BIOCHEMISTRY$$x0004-5632
000097463 8564_ $$s251959$$uhttps://zaguan.unizar.es/record/97463/files/texto_completo.pdf$$yVersión publicada
000097463 8564_ $$s41049$$uhttps://zaguan.unizar.es/record/97463/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097463 909CO $$ooai:zaguan.unizar.es:97463$$particulos$$pdriver
000097463 951__ $$a2022-06-21-09:40:15
000097463 980__ $$aARTICLE