97463 20220621094623.0 doi 10.1177/0004563220980495 sideral 121660 ART-2020-121660 eng Fabre, M. SARS-CoV-2 immunochromatographic IgM/IgG rapid test in pregnancy: A false friend? 2020 Access copy available to the general public Unrestricted Background: An increasing body of evidence has revealed that SARS-CoV-2 infection in pregnant women could increase the risk of adverse maternal and fetal outcomes. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted. Therefore, rapid antibody tests have been suggested as an efficient screening tool during pregnancy. Cases: We analysed the clinical performance during pregnancy of a rapid, lateral-flow immunochromatographic assay for qualitative detection of SARS-CoV-2 IgG/IgM antibodies. We performed a universal screening including 169 patients during their last trimester of pregnancy. We present a series of 14 patients with positive SARS-CoV-2 immunochromatographic assay rapid test result. Immunochromatographic assay results were always confirmed by chemiluminescent microparticle immunoassays for quantitative detection of SARS-CoV-2 IgG and IgM+IgA antibodies as the gold standard. We observed a positive predictive value of 50% and a false positive rate of 50% in pregnant women, involving a significantly lower diagnostic performance than reported in non-pregnant patients. Discussion: Our data suggest that although immunochromatographic assay rapid tests may be a fast and profitable screening tool for SARS-CoV-2 infection, they may have a high false positive rate and low positive predictive value in pregnant women. Therefore, immunochromatographic assay for qualitative detection of SARS-CoV-2 IgG/IgM antibodies must be verified by other test in pregnant patients. info:eu-repo/grantAgreement/ES/ISCIII/CM18-00202 info:eu-repo/grantAgreement/ES/ISCIII/JR19-00006 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.057 2020 MEDICAL LABORATORY TECHNOLOGY 20 / 29 = 0.69 2020 Q3 T3 0.6 2020 Medicine (miscellaneous) 2020 Q2 Clinical Biochemistry 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ruiz-Martinez, S. Monserrat Cantera, M.E. Cortizo Garrido, A. Beunza Fabra, Z. Peran, M. Benito, R. Universidad de Zaragoza (orcid)0000-0001-5134-1006 Mateo, P. Universidad de Zaragoza (orcid)0000-0002-2218-5240 Paules, C. Universidad de Zaragoza (orcid)0000-0001-6795-0367 Oros, D. Universidad de Zaragoza (orcid)0000-0002-8476-9161 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1013 645 Universidad de Zaragoza Dpto. Cirugía Área Obstetricia y Ginecología 58, 2 (2020), 149-152 Ann. clin. biochem. ANNALS OF CLINICAL BIOCHEMISTRY 0004-5632 251959 http://zaguan.unizar.es/record/97463/files/texto_completo.pdf Versión publicada 41049 http://zaguan.unizar.es/record/97463/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:97463 articulos driver 2022-06-21-09:40:15 ARTICLE