000098198 001__ 98198
000098198 005__ 20230914083322.0
000098198 0247_ $$2doi$$a10.1183/23120541.00122-2020
000098198 0248_ $$2sideral$$a121563
000098198 037__ $$aART-2020-121563
000098198 041__ $$aeng
000098198 100__ $$aDivo, M.J.
000098198 245__ $$aSomatotypes trajectories during adulthood and their association with COPD phenotypes
000098198 260__ $$c2020
000098198 5060_ $$aAccess copy available to the general public$$fUnrestricted
000098198 5203_ $$aRationale: Chronic obstructive pulmonary disease (COPD) comprises distinct phenotypes, all characterised by airflow limitation.
Objectives: We hypothesised that somatotype changes - as a surrogate of adiposity - from early adulthood follow different trajectories to reach distinct phenotypes.
Methods: Using the validated Stunkard''s Pictogram, 356 COPD patients chose the somatotype that best reflects their current body build and those at ages 18, 30, 40 and 50 years. An unbiased group-based trajectory modelling was used to determine somatotype trajectories. We then compared the current COPD-related clinical and phenotypic characteristics of subjects belonging to each trajectory.
Measurements and main results: At 18 years of age, 88% of the participants described having a lean or medium somatotype (estimated body mass index (BMI) between 19 and 23 kg.m(-2)) while the other 12% a heavier somatotype (estimated BMI between 25 and 27 kg.m(-2)). From age 18 onwards, five distinct trajectories were observed. Four of them demonstrating a continuous increase in adiposity throughout adulthood with the exception of one, where the initial increase was followed by loss of adiposity after age 40. Patients with this trajectory were primarily females with low BMI and D-LCO (diffusing capacity of the lung for carbon monoxide). A persistently lean trajectory was seen in 14% of the cohort. This group had significantly lower forced expiratory volume in 1 s (FEV1), D-LCO, more emphysema and a worse BODE (BMI, airflow obstruction, dyspnoea and exercise capacity) score thus resembling the multiple organ loss of tissue (MOLT) phenotype.
Conclusions: COPD patients have distinct somatotype trajectories throughout adulthood. Those with the MOLT phenotype maintain a lean trajectory throughout life. Smoking subjects with this lean phenotype in early adulthood deserve particular attention as they seem to develop more severe COPD.
000098198 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000098198 592__ $$a0.519$$b2020
000098198 593__ $$aPulmonary and Respiratory Medicine$$c2020$$dQ3
000098198 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000098198 700__ $$aOto, M.M.
000098198 700__ $$aMacario, C.C.
000098198 700__ $$aLopez, C.C.
000098198 700__ $$ade-Torres, J.P.
000098198 700__ $$0(orcid)0000-0001-9096-2294$$aMarin Trigo, J.M.$$uUniversidad de Zaragoza
000098198 700__ $$aHersh, C.P.
000098198 700__ $$aCasajus, A.E.
000098198 700__ $$aMaguire, C.
000098198 700__ $$aPinto-Plata, V.M.
000098198 700__ $$aPolverino, F.
000098198 700__ $$aRoss, J.C.
000098198 700__ $$aDeMeo, D.
000098198 700__ $$aBastarrika, G.
000098198 700__ $$aSilverman, E.K.
000098198 700__ $$aCelli, B.R.
000098198 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000098198 773__ $$g6, 3 (2020), 00122-2020 [9pp]$$pERJ open res.$$tERJ Open Research$$x2312-0541
000098198 8564_ $$s813165$$uhttps://zaguan.unizar.es/record/98198/files/texto_completo.pdf$$yVersión publicada
000098198 8564_ $$s2151727$$uhttps://zaguan.unizar.es/record/98198/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000098198 909CO $$ooai:zaguan.unizar.es:98198$$particulos$$pdriver
000098198 951__ $$a2023-09-13-11:05:05
000098198 980__ $$aARTICLE