000098221 001__ 98221
000098221 005__ 20210120124310.0
000098221 0247_ $$2doi$$a10.1371/journal.pone.0224500
000098221 0248_ $$2sideral$$a121869
000098221 037__ $$aART-2019-121869
000098221 041__ $$aeng
000098221 100__ $$aBoquete, L.
000098221 245__ $$aDiagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method
000098221 260__ $$c2019
000098221 5060_ $$aAccess copy available to the general public$$fUnrestricted
000098221 5203_ $$aPurpose
To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS).
Methods
We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F: M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor.
Results
The standard method of analysis obtains further discrimination between controls and MS in ring R3 (AUC = 0.82), analysing N1 waves amplitudes. In all of the retina analysis regions, FNRMSE value shows a greater discriminating power than the standard method. The highest AUC value (AUC = 0.91) was in the superior temporal quadrant.
Conclusion
By analysing mfERG recordings and contrasting them with those of healthy controls it is possible to detect early-stage MS in patients without a previous history of ON.
000098221 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008-020$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008-029$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/DPI2017-88438-R
000098221 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000098221 590__ $$a2.74$$b2019
000098221 591__ $$aMULTIDISCIPLINARY SCIENCES$$b27 / 71 = 0.38$$c2019$$dQ2$$eT2
000098221 592__ $$a1.023$$b2019
000098221 593__ $$aMultidisciplinary$$c2019$$dQ1
000098221 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000098221 700__ $$aLópez-Guillén, E.
000098221 700__ $$aVilades, E.
000098221 700__ $$aMiguel-Jiménez, J.M.
000098221 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000098221 700__ $$ade Santiago, L.
000098221 700__ $$adel Castillo, M.O.
000098221 700__ $$aAlonso-Rodríguez, M.C.
000098221 700__ $$aMorla, E.M.S.
000098221 700__ $$aLópez-Dorado, A.
000098221 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000098221 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000098221 773__ $$g14, 11 (2019), e0224500 [12 pp]$$pPLoS One$$tPloS one$$x1932-6203
000098221 8564_ $$s608443$$uhttps://zaguan.unizar.es/record/98221/files/texto_completo.pdf$$yVersión publicada
000098221 8564_ $$s2092636$$uhttps://zaguan.unizar.es/record/98221/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000098221 909CO $$ooai:zaguan.unizar.es:98221$$particulos$$pdriver
000098221 951__ $$a2021-01-20-10:41:30
000098221 980__ $$aARTICLE