98231 20210121103728.0 doi 10.1039/c9nj02392e sideral 112967 ART-2019-112967 eng Sonsona, I.G. First aromatic amine organocatalysed activation of alpha, beta- unsaturated ketones 2019 Access copy available to the general public Unrestricted This work provides an unprecedented example of a chiral aromatic amine used to activate a, b-unsaturated ketones in asymmetric aminocatalysis. Chiral aromatic diamine VII has been efficiently employed, as a proof of concept, in the Michael addition reaction between benzylideneacetones (1a-f) and coumarins (2a-d). The reaction gives rise to warfarin derivatives 3 with promising results using this family of catalysts for the first time. The additional studies performed supported the bifunctional mode of activation of the chiral catalyst VII and the covalent nature of the interactions between the catalyst VII and benzylideneacetones 1. info:eu-repo/grantAgreement/ES/DGA/E07-17R info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-75816-C2-1-P info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2017-88091-P info:eu-repo/grantAgreement/ES/UZ/JIUZ-2017-CIE-05 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 3.288 2019 CHEMISTRY, MULTIDISCIPLINARY 68 / 177 = 0.384 2019 Q2 T2 0.712 2019 Materials Chemistry 2019 Q1 Chemistry (miscellaneous) 2019 Q2 Catalysis 2019 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-6832-8983 Marques-Lopez, E. Universidad de Zaragoza (orcid)0000-0003-0553-0695 Gimeno, M.C. Universidad de Zaragoza Herrera, R.P. 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 43, 31 (2019), 12233-12240 New j. chem. NEW JOURNAL OF CHEMISTRY 1144-0546 3404365 http://zaguan.unizar.es/record/98231/files/texto_completo.pdf Versión publicada 2796974 http://zaguan.unizar.es/record/98231/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:98231 articulos driver 2021-01-21-08:12:05 ARTICLE