Management and outcomes of gastrointestinal congenital anomalies in low, middle and high income countries: Protocol for a multicentre, international, prospective cohort study

Wright, N.J.; Hagander, L.; Hashim, S.; Ade-Ajayi, N.; Williams, I.; Riboni, C.; Karim, S.; Tarrado, X.; Owusu, S.; Tabiri, S.; Soomro, A.; Vaitkiene, A.; Nour, I.; Abdul-Mumin, A.; Yunus, A.; Poenaru, D.; Martinez-Leo, B.; Parker, S.; Thompson, H.; Sarhan, O.A.K.; Qureshi, T.; Philipo, G.S.; Garcia-Aparicio, L.; Bragagnini, P.; Choo, C.S.C.; Herrera, L.; Ameh, E.; Adofo-Ansong, N.; Nour, I.R.; Bagbio, D.; Sevdalis, N.; Shinondo, P.; Arbab, H.; Amjad, M.B.; Alhamid, A.; Iriondo, M.; Khattak, M.A.K.; Mitul, A.R.; Smith, E.; Aziz, D.A.A.; Naranjo, K.; Yousaf, H.; Kwasau, H.; Vervoort, D.; Elrais, S.A.; Ademuyiwa, A.; Salem, H.K.; Akhbari, M.; Ismavel, V.A.; Anaya, M.D.; Ubhi, H.; Liu, Y.; Alser, O.H.; Sim, M.; Dimatatac, D.M.; Aydin, E.; Chaudhary, M.A.; Rite, S.; Leather, A.; Abukhalaf, S.; Ivanov, M.; Arshad, M.; Davies, J.; Shajin, T.; Samad, L.; Nah, S.A.; Lakhoo, K.; Al-Taher, R.N.; Hyman, G.; Hasan, S.; Elghazaly, S.M.; Serban, A.; Benaskeur, Y.I.; Saleh, M.; Miriam, A.; Wright, N.; Svensson, E.; Prat, J.; Maistry, N.; Blazquez-Gomez, E.

doi:10.1136/bmjopen-2019-030452

000098276 001__ 98276
000098276 005__ 20210122153456.0
000098276 0247_ $$2doi$$a10.1136/bmjopen-2019-030452
000098276 0248_ $$2sideral$$a121994
000098276 037__ $$aART-2019-121994
000098276 041__ $$aeng
000098276 100__ $$aWright, N.J.
000098276 245__ $$aManagement and outcomes of gastrointestinal congenital anomalies in low, middle and high income countries: Protocol for a multicentre, international, prospective cohort study
000098276 260__ $$c2019
000098276 5060_ $$aAccess copy available to the general public$$fUnrestricted
000098276 5203_ $$aIntroduction 
Congenital anomalies are the fifth leading cause of death in children <5 years of age globally, contributing an estimated half a million deaths per year. Very limited literature exists from low and middle income countries (LMICs) where most of these deaths occur. The Global PaedSurg Research Collaboration aims to undertake the first multicentre, international, prospective cohort study of a selection of common congenital anomalies comparing management and outcomes between low, middle and high income countries (HICs) globally. 
Methods and analysis 
The Global PaedSurg Research Collaboration consists of surgeons, paediatricians, anaesthetists and allied healthcare professionals involved in the surgical care of children globally. Collaborators will prospectively collect observational data on consecutive patients presenting for the first time, with one of seven common congenital anomalies (oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation and Hirschsprung''s disease). Patient recruitment will be for a minimum of 1 month from October 2018 to April 2019 with a 30-day post-primary intervention follow-up period. Anonymous data will be collected on patient demographics, clinical status, interventions and outcomes using REDCap. Collaborators will complete a survey regarding the resources and facilities for neonatal and paediatric surgery at their centre. The primary outcome is all-cause in-hospital mortality. Secondary outcomes include the occurrence of postoperative complications. Chi-squared analysis will be used to compare mortality between LMICs and HICs. Multilevel, multivariate logistic regression analysis will be undertaken to identify patient-level and hospital-level factors affecting outcomes with adjustment for confounding factors. 
Ethics and dissemination 
At the host centre, this study is classified as an audit not requiring ethical approval. All participating collaborators have gained local approval in accordance with their institutional ethical regulations. Collaborators will be encouraged to present the results locally, nationally and internationally. The results will be submitted for open access publication in a peer reviewed journal.
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000098276 700__ $$aWright, N.
000098276 700__ $$aAde-Ajayi, N.
000098276 700__ $$aAdemuyiwa, A.
000098276 700__ $$aAmeh, E.
000098276 700__ $$aDavies, J.
000098276 700__ $$aLakhoo, K.
000098276 700__ $$aPoenaru, D.
000098276 700__ $$aSevdalis, N.
000098276 700__ $$aSmith, E.
000098276 700__ $$aLeather, A.
000098276 700__ $$aUbhi, H.
000098276 700__ $$aParker, S.
000098276 700__ $$aPhilipo, G.S.
000098276 700__ $$aAbukhalaf, S.
000098276 700__ $$aAdofo-Ansong, N.
000098276 700__ $$aAkhbari, M.
000098276 700__ $$aAlhamid, A.
000098276 700__ $$aAlser, O.H.
000098276 700__ $$aAydin, E.
000098276 700__ $$aBenaskeur, Y.I.
000098276 700__ $$aElghazaly, S.M.
000098276 700__ $$aElrais, S.A.
000098276 700__ $$aHashim, S.
000098276 700__ $$aHerrera, L.
000098276 700__ $$aHyman, G.
000098276 700__ $$aKwasau, H.
000098276 700__ $$aLiu, Y.
000098276 700__ $$aMartinez-Leo, B.
000098276 700__ $$aNaranjo, K.
000098276 700__ $$aNour, I.
000098276 700__ $$aRiboni, C.
000098276 700__ $$aSaleh, M.
000098276 700__ $$aSalem, H.K.
000098276 700__ $$aShinondo, P.
000098276 700__ $$aSim, M.
000098276 700__ $$aThompson, H.
000098276 700__ $$aVaitkiene, A.
000098276 700__ $$aVervoort, D.
000098276 700__ $$aWilliams, I.
000098276 700__ $$aYunus, A.
000098276 700__ $$aChaudhary, M.A.
000098276 700__ $$aKhattak, M.A.K.
000098276 700__ $$aAmjad, M.B.
000098276 700__ $$aAnaya, M.D.
000098276 700__ $$aHasan, S.
000098276 700__ $$aKarim, S.
000098276 700__ $$aMitul, A.R.
000098276 700__ $$aBragagnini, P.
000098276 700__ $$0(orcid)0000-0002-9641-0324$$aRite, S.$$uUniversidad de Zaragoza
000098276 700__ $$aArbab, H.
000098276 700__ $$aSamad, L.
000098276 700__ $$aSoomro, A.
000098276 700__ $$aMaistry, N.
000098276 700__ $$aAl-Taher, R.N.
000098276 700__ $$aNour, I.R.
000098276 700__ $$aSarhan, O.A.K.
000098276 700__ $$aArshad, M.
000098276 700__ $$aQureshi, T.
000098276 700__ $$aYousaf, H.
000098276 700__ $$aChoo, C.S.C.
000098276 700__ $$aDimatatac, D.M.
000098276 700__ $$aNah, S.A.
000098276 700__ $$aIsmavel, V.A.
000098276 700__ $$aMiriam, A.
000098276 700__ $$aShajin, T.
000098276 700__ $$aIvanov, M.
000098276 700__ $$aSerban, A.
000098276 700__ $$aMartinez-Leo, B.
000098276 700__ $$aBlazquez-Gomez, E.
000098276 700__ $$aGarcia-Aparicio, L.
000098276 700__ $$aIriondo, M.
000098276 700__ $$aPrat, J.
000098276 700__ $$aTarrado, X.
000098276 700__ $$aHagander, L.
000098276 700__ $$aSvensson, E.
000098276 700__ $$aAbdul-Mumin, A.
000098276 700__ $$aBagbio, D.
000098276 700__ $$aOwusu, S.
000098276 700__ $$aTabiri, S.
000098276 700__ $$aAziz, D.A.A.
000098276 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Pediatría
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000098276 951__ $$a2021-01-22-13:53:17
000098276 980__ $$aARTICLE

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