doi:10.23919/CinC49843.2019.9005863engMountris, K.A.Sanchez, C.Pueyo, E.A Novel Paradigm for in Silico Simulation of Cardiac Electrophysiology Through the Mixed Collocation Meshless Petrov-Galerkin MethodART-2019-121995Multi-scale cardiac electrophysiological modeling involves high computational load due to the inherent complexity as well as to limitations of the employed numerical methods (e.g., Finite Element Method - FEM). This study investigates the use of the Meshless Local Petrov-Galerkin Mixed Collocation (MLPG-MC) method to simulate cardiac electrophysiology. MLPG-MC is a truly meshless method where both the unknown function and its gradient are interpolated using nodal collocation. A 3 cm × 3 cm human ventricular tissue was simulated based on the monodomain reaction-diffusion model using the operator splitting technique. MLPG-MC or FEM were used to solve the diffusion term and the O''Hara-Virág-Varró-Rudy AP model to represent cellular electrophysiology at baseline and under 30% IKr inhibition (IKr30). Mean differences between MLPG-MC and FEM in AP duration at 90% (APD90), 50% (APD50) and 20% (APD20) repolarization levels were 4.47%, 4.16% and 3.29% for baseline conditions and 3.66%, 2.10% and 1.62% for IKr30 conditions. The computational time associated with each of the two methods was comparable. In conclusion, considering that MLPG-MC does not involve any mesh requirements and is well suited for massive parallelization, this study shows that it represents a promising alternative to FEM for cardiac electrophysiology simulations.2019http://zaguan.unizar.es/record/9827710.23919/CinC49843.2019.9005863http://zaguan.unizar.es/record/98277oai:zaguan.unizar.es:98277info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoSinfo:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-RComputing in Cardiology 46 (2019), [4 pp]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess